The Root Cause Medicine Podcast

The research around SIBO is evolving, and 2026 has brought more subtypes, testing and treatment options than ever before. Our guest this week, Dr. Allison Siebecker, is an expert in conventional and natural approaches to SIBO, helped to open one of the first integrative SIBO centers in the nation, and frequently teaches physicians about how to effectively treat even the toughest cases of SIBO, ISO, IMO and more. Today, we explore how hydrogen, methane (IMO), and hydrogen sulfide–associated (ISO) pattern-typing can help us choose treatment options that help to decrease SIBO symptoms effectively. We discuss how impaired motility - particularly dysfunction of the migrating motor complex - can impact symptom persistence and relapse in addition to microbial type and load, and why we should address it in treatment plans. Dr. Siebecker also reviews the newest advances in SIBO testing, breath test interpretation, and how long to test depending on what you’re looking to discover. If SIBO has felt like a guessing game in your practice, or if you’re just looking to stay on the leading edge, this episode offers a clearer, physiology-driven framework grounded in education that will help your clients get and stay well.

This episode of the Root Cause Medicine Podcast features host Dr. Kate Kresge, ND in conversation with Dr. Jeff Gladd, MD, Chief Medical Officer at Fullscript and an integrative primary care physician. Together, they unpack three timely topics for whole-person clinicians: emerging human data on urolithin A as a mitophagy-activating postbiotic that may support mitochondrial function and immune aging; how to help patients engage with the “fiber maxing” trend in a safe, sustainable way that supports metabolic health, GI function, and diet adherence; and a new industry survey showing that 94% of pharma leaders are running or exploring direct-to-patient (DTP) programs, with implications for GLP-1 therapy access, continuity of care, and the clinician’s central role in guiding treatment decisions. (Nature)

In this episode of the Root Cause Medicine Podcast, Dr. Kate Kresge is joined by Dr. Eric Viegas, a leader in supplement safety at Fullscript, for a timely and evidence-informed discussion on lead exposure in protein powders and nutritional supplements. Amid rising media attention and consumer concern, the conversation unpacks how and why trace amounts of lead can appear in supplements, how different regulatory thresholds (Prop 65 vs. USP/ICH) should be interpreted clinically, and what toxicologically relevant exposure actually means. Clinicians will gain practical insight into cumulative lead exposure, patient risk stratification, and how Fullscript is advancing supplement quality through enhanced testing, transparency, and practitioner-facing safeguards.

In this “Health or Hype” rapid-fire episode, Dr. Kate Kresge teams up with Dr. Chris Sands, DPT, OCS, and Dr. Gabe Kresge, DPT, to sort running fact from fiction. They break down why strength training rarely “bulks up” runners and more often boosts efficiency, why single-leg strength better reflects the true demands of running than squats alone, and why minimalist shoes (and cushioning) should be chosen based on individual capacity and a gradual transition. They also address joint health—explaining why moderate, well-programmed running isn’t automatically “wear and tear”—and close with a practical prevention message: running assessments can catch issues before pain starts, and most injuries trace back to training load and under-recovery more than biomechanics.

This episode of the Root Cause Medicine Podcast explores the Modern Running Assessment, an evidence-informed, data-driven framework for evaluating runners’ biomechanics, load tolerance, and performance capacity. Host Dr. Kate Kresge interviews Dr. Chris Sands, DPT, OCS, and Dr. Gabe Kresge, DPT, from Kinetic Physical Therapy to examine how modern tools—dynamometry, force plate testing, slow-motion gait analysis, cadence and vertical oscillation metrics, and single-leg endurance testing—provide objective information that visual observation alone may miss. These measurable insights help clinicians better understand strength-to-body-weight ratios, inter-limb asymmetries, foot-strike loading patterns, and fatigue-related movement changes, offering a clearer picture of the factors that may influence running efficiency, durability, and injury risk.

We’re launching a new series that brings the insights that Fullscript Chief Medical Officer Dr. Jeff Gladd normally shares only with our internal team—now open to the entire integrative and functional medicine community. This month, Dr. Gladd breaks down three emerging clinical priorities with immediate relevance to whole-person care. He covers why the American College of Cardiology is now recommending high-sensitivity CRP (hs-CRP) for universal cardiovascular screening, how grip strength paired with BMI is outperforming traditional biomarkers in predicting metabolic decline and all-cause mortality risk, and what new evidence tells us about saffron as supportive care for patients experiencing SSRI-related sexual side effects.

This episode features Dr. Neda Gioia, OD, CNS®, IFMCP, a pioneer in integrative eye care who blends optometry, clinical nutrition, and functional medicine to advance preventive vision strategies. Clinicians will learn how gut-eye axis mechanisms, AI-driven oculomics, sex-hormone transitions, and nutrient patterns influence ocular inflammation, retinal biomarkers, and whole-system health. Dr. Gioia illustrates how modern imaging (including emerging AI models), stool and hormone testing, and nutrient evaluation can support earlier identification of risk patterns and more personalized, prevention-forward care for patients across the lifespan.

In this inspiring episode of the Root Cause Medicine Podcast, Dr. Kate Kresge welcomes Dr. Cynthia Libert, a board-certified family physician, functional medicine expert, and creator of The Joy Prescription. Together they explore the biochemistry of joy, how gratitude reshapes brain connectivity, and how positive emotion can help to modulate inflammation, support neuroplasticity, and protect cognitive health. Clinicians will learn practical ways to integrate “joy prescriptions” into patient care, using evidence-informed tools to foster resilience and prevent burnout.

In this episode of The Root Cause Medicine Podcast, Dr. Kate Kresge interviews Dr. Chris Magryta and Dr. Erik Lundquist about Advanced Blood Labs 201—a course designed to help clinicians interpret metabolic and immune biomarkers across pediatric and adult populations. They explain how to use tests like C-peptide, adiponectin, leptin, and glutathione to identify early metabolic stress, and explore immune indices such as SII (Systemic Immune Inflammation Index) and SIRI (Systemic Inflammation Response Index) to uncover inflammation trends in both children and adults.

James Greenblatt explores the evolving science of low-dose lithium as a neuroprotective intervention — highlighting its potential to prevent, slow, and even reverse cognitive decline associated with Alzheimer’s disease. He emphasizes that safe, nutritional lithium (2-10 mg) can support brain health by reducing neuroinflammation, promoting neuroregeneration, and stabilizing mood—without the risks associated with pharmaceutical doses. Clinicians are encouraged to assess lithium status through hair mineral analysis, monitor thyroid and kidney function, and consider environmental and dietary influences on endogenous lithium levels. By integrating low-dose lithium into a comprehensive, individualized care plan—including lifestyle modifications and targeted testing—practitioners can leverage this simple mineral to support mental clarity, impulsivity regulation, and long-term cognitive resilience.