Progress, Potential, and Possibilities Podcast / Show

Send us Fan MailDr. Brian A. Grierson, Ph.D. is a leading physicist and engineer in magnetic fusion energy and is currently Director of Fusion Energy Technologies at General Atomics ( https://www.ga.com/ ) in San Diego. In this role, he leads the technical vision, design strategy, and integration of plasma physics, engineering, diagnostics, and tritium fuel‐cycle technologies for fusion pilot‐plants aimed at moving fusion from experimental facilities toward viable commercial power ( https://www.ga.com/magnetic-fusion/ ).Dr. Grierson’s career bridges academic research and applied development. He earned his B.S. from the University of Wisconsin–Madison in 2004, majoring in Applied Mathematics, Engineering & Physics, with emphases in nuclear engineering and plasma physics. He then pursued graduate studies at Columbia University, where he obtained his M.S. (2005), M.Phil. (2008), and Ph.D. in Applied Physics and Applied Mathematics in 2009, defending a dissertation titled “Interchange Turbulence in a Dipole‐Confined Plasma.” After his Ph.D., Dr. Grierson joined the Princeton Plasma Physics Laboratory ( PPPL - https://www.pppl.gov/ ), working on experimental diagnostics and plasma behavior at the DIII‐D National Fusion Facility ( operated by GA - https://d3dfusion.org/ ) and other tokamak projects. Over several years Dr. Grierson held roles including Associate Research Physicist, Staff Physicist, and Research Physicist within PPPL’s ITER & Tokamaks Department, and led groups focused on the plasma edge (“pedestal”), ion transport, and diagnostics development. In 2014, Dr. Grierson was awarded a U.S. Department of Energy Early Career Research Program grant to advance diagnostics of main‐ion behavior at the edge of fusion plasmas — work critical for understanding confinement, stability, and performance of devices like ITER and future tokamaks. In recognition of his research contributions, Dr. Grierson received the Kaul Foundation Prize for Excellence in Plasma Physics Research and Technology Development in 2017. In 2021, he joined General Atomics to direct the Fusion Pilot Plant Design Hub and served as Director of the Fusion Pilot Plant Design Hub for 4 years. Under his leadership, GA has put forth a concept for a compact advanced steady‐state tokamak Fusion Pilot Plant (FPP) that draws on innovations in plasma physics, simulation tools like the proprietary FUSE (Fusion Synthesis Engine), modular breeding blanket design, materials engineering, control, diagnostics, and systems integration ( https://www.ga.com/magnetic-fusion/promise-of-fusion ). Dr. Grierson has also played a major role in partnerships such as GA’s collaboration with Savannah River National Laboratory ( https://www.srnl.gov/ ) to address tritium fuel handling — a critical component of making fusion power practical. General Atomics (GA) is an American energy and defense corporation headquartered in San Diego, California, that specializes in research and technology development. This includes physics research in support of nuclear fission and nuclear fusion energy. The company also provides research and manufacturing services for remotely operated surveillance aircraft, including its MQ-1 Predator drones, airborne sensors, and advanced electric, electronic, wireless, and laser technologies.#BrianGrierson #GeneralAtomics #FusionEnergy #Nuclear #ITER #Thermonuclear #Tokamak #ExperimentalPhysics #Energy #PlasmaPhysics #NuclearFusion #Tritium #Deuterium #CollisionlessTerrellaExperiment #InertialConfinementFusion #NationalIgnitionFacility #MagneticConfinementFusion #SustainedPlasmaBurns #FuelCycle #ElectricityGeneration #BurningPlasma #TritiumBreeding #BreedingBlankets #EdgePlasma #ProgressPotentialAndPossibSupport the show

Send us Fan MailDr. Aliza Apple, Ph.D. is a Vice President of Catalyze360 AI ( https://www.lilly.com/science/partners/catalyze-360 ) and Global Head of Lilly TuneLab ( https://tunelab.lilly.com/ ) at Eli Lilly where she leads the strategy, build and launch of Lilly’s external-facing AI/ML efforts for drug discovery.Lilly Catalyze360 represents a comprehensive approach to enabling the early-stage biotech ecosystem, agnostic of the therapeutic area, designed to accelerate emerging and promising science, strategically removing barriers to support biotech innovation.In her previous role at Lilly, Dr. Apple served as the COO and head of Lilly Gateway Labs West Coast, where she supported the local biotech ecosystem through early engagement and providing tailored offerings to meet their needs. Prior to Lilly,  Dr. Apple served as a co-founder at Santa Ana Bio, a venture-backed precision biologics company focused on autoimmune disease, and as an advisor to the founders of Firefly Biologics. Prior to biotech, Dr. Apple was a partner in McKinsey & Co’s life sciences practice. During her nine years at McKinsey in New York and San Francisco, she collaborated with leaders from over 20 biopharma companies to develop their corporate and portfolio strategies, evaluate business development opportunities and improve their organizational effectiveness. Dr. Apple completed her Ph.D. in bioengineering at UC Berkeley and UCSF, and holds a Bachelor of Science in physics from Georgetown University. She completed a postdoctoral fellowship at Cornell Medical College supported by the NIH Kirschtein National Research Service Award.#AlizaApple #Catalyze360 #TuneLab #EliLilly #LillyGatewayLabs #DrugDiscoveryModels #SmallMolecules #AntibodyTherapeutics #InSilicoPropertyPredictions #AI #ML #ArtificialIntelligence #MachineLearning #LillyVentures #InnovationHubs #Preclinical #DiscoveryChemistry #StructuralBiology #Toxicology #Immunogenicity #DrugMetabolism #Pharmacokinetics #Pharmacodynamics #ClinicalOperations #SmallMoleculeDrugDevelopment #LargeMoleculeDiscoveryProcess #CorporateVentureCapital #STEM #Innovation #Science #Technology #Research #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #Podcasting #ViralPodcastSupport the show

Send us Fan MailDr. Leonard Petrucelli, PhD ( https://www.mayo.edu/research/faculty/petrucelli-leonard-ph-d/bio-00027816 ), is a leading translational neuroscientist and Professor in the Department of Neuroscience at Mayo Clinic — Jacksonville, where he leads the Neurodegenerative Diseases Laboratory ( https://www.mayo.edu/research/labs/neurodegenerative-diseases/overview ). Dr. Petrucelli’s lab seeks to understand and prevent neuronal degeneration and death in diseases characterized by abnormal protein aggregation and defects in RNA metabolism. His team uses a combination of cell biology, induced pluripotent stem cell technology, transcriptomics and mouse modeling to gain insight into disease mechanisms. They then leverage their findings to develop new therapeutic strategies and clinical tools tailored for these complicated disorders. Their current work focuses on a range of conditions, including Alzheimer's disease, frontotemporal dementia and amyotrophic lateral sclerosis (ALS).Dr. Petrucelli trained in molecular and cellular biochemistry (Ph.D., Loyola University & Stritch School of Medicine) after earning a B.S. in Biology from Barry University, and he joined Mayo Clinic as a research fellow before rising to professor and department chair. His group combines human neuropathology, cell and molecular biology, and animal models to connect disease-linked genes and protein misprocessing to neuronal dysfunction and degeneration. Scientifically, Dr. Petrucelli is best known for mechanistic work on aggregation-prone proteins and pathways that underlie neurodegeneration — including seminal contributions on TDP-43 biology, progranulin (GRN) dysfunction, and pathogenic mechanisms associated with C9orf72 repeat expansions — and for translating those findings toward biomarkers and therapeutic strategies. His lab’s work appears in high-impact journals and has helped define key pathogenic cascades now pursued by academic and industry drug-development programs. Beyond his laboratory, Dr. Petrucelli serves in prominent advisory and leadership roles across the field: he is a voice on state and national Alzheimer’s advisory efforts, has advised disease-focused nonprofits and consortia (including Target ALS and others), and participates on scientific advisory boards for translational ventures. He is also an R35 (Research Program Award) recipient and an investigator with an extensive record of NIH-supported projects investigating mechanisms and potential interventions for FTD/ALS and related dementias. #LeonardPetrucelli #Neuroscience #Neurodegenerative #MayoClinic #Proteinopathies #Tauopathies #AlzheimersDisease #ParkinsonsDisease #AmyotrophicLateralSclerosis #HuntingtonsDisease #PrionDiseases #CreutzfeldtJakobDisease #ProgressiveSupranuclearPalsy #CorticobasalDegeneration #FrontotemporalDementia #ChronicTraumaticEncephalopathy #RichardRainwater #BruceWillis #TauopathyChallenge #RainwaterFoundation #AgingMindFoundation #AlzheimersAssociation #CurePSP #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #ViralPodcast #STEM #Innovation #Technology #Science #ResearchSupport the show

Send us Fan MailDr. Robert Allen, PhD is Chief Scientific Officer of Invivyd ( https://www.invivyd.com/ ), a biopharmaceutical company devoted to delivering protection from serious viral infectious diseases, beginning with SARS-CoV-2, by deploying a proprietary integrated technology platform, to create best in class monoclonal antibodies.Dr. Allen brings over 30 years of experience across the infectious disease space, most recently as the Chief Scientific Officer of SmartPharm Therapeutics, a subsidiary of Sorrento Therapeutics. During that time, he led efforts to develop gene-encoded monoclonal antibodies for COVID-19 that could be quickly adapted to respond to emerging variants of concern. He also served concurrently as Senior Vice President, Antiviral and Oncolytic Immunotherapy Development, at Sorrento Therapeutics. Prior to his time at SmartPharm Therapeutics, Dr. Allen held multiple senior scientific roles across the pharmaceutical and biotechnology industries including at Sorrento Therapeutics, SIGA Technologies, and the Oregon Translational Research and Development Institute. Dr. Allen holds a Ph.D. in Microbiology from Columbia University, an M.S. in Applied Biology from Georgia Institute of Technology, and a B.S. in Biology from Rhodes College. He has published extensively in the field of virology and completed his postdoctoral training in virology at Washington University in St. Louis and Emory University.#RobertAllen #Invivyd #Biopharmaceuticals #InfectiousDiseases #SARSCoV2 #MonoclonalAntibodies #Immunocompromised #RareViralEpitopes #Pemivibart #PreExposureProphylaxis #Covid19 #EmergencyUseAuthorization #EUA #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #ViralPodcast #STEM #Innovation #Technology #Science #ResearchSupport the show

Send us Fan MailDr. Mark Lloyd Davies, Ph.D. is the Global Head for the Strategic Partnerships and Resource Group at Johnson & Johnson ( https://www.jnj.com/ ) where he leads a global team that forges novel strategic public-private partnerships to secure collaborations that accelerate groundbreaking R&D, advances strategies that widen access to care for patients and health systems worldwide, and ultimately unlocks possibilities that transform lives.Dr. Davies has built a distinguished career at the intersection of science, policy, and global health strategy.Before taking on his current global role, Dr. Davies held a number of senior leadership positions within Johnson & Johnson, where he was instrumental in shaping external engagement strategies and guiding policy development in areas ranging from pharmaceutical innovation to public health preparedness, leading strategic initiatives such as the Johnson & Johnson Lung Cancer Initiative.Dr. Davies was previously Chair of the Med Tech Europe Research & Innovation Committee, where he worked on the evolution of the EU funded Innovative Medicines Initiative, as well as at Sanofi, involved in various External Affairs initiatives.Dr. Davies holds a Ph.D. from the University of Amsterdam, The Netherlands, in Climate Change, Physical Geography and Geology, and a BSc, Biology and Geography, Earth Sciences, Climate Change, from the University of London, UK.#MarkLloydDavies #StrategicPartnershipsAndResourceGroup #JohnsonAndJohnson #PublicPrivatePartnerships #MedTechEurope #InnovativeMedicinesInitiative #InnovativeHealthInitiative #OperationWarpSpeed #LungCancerInitiative #GlobalNeurodegenerationProteomicsConsortium #Antarctica #ClimateChange #PhysicalGeography #Geology #CARBX #DrugsForNeglectedDiseasesInitiative #STEM #Innovation #Science #Technology #Research #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #Podcasting #ViralPodcastSupport the show

Send us Fan MailWade Demmer is Vice President of Research & Development at Medtronic where he is responsible for the development of new generations of pacemakers ( https://www.medtronic.com/en-us/l/patients/treatments-therapies/pacemakers.html ). With extensive expertise in medical technology and innovation, he leads the company's R&D efforts to develop cutting-edge healthcare solutions and is dedicated to advancing medical advancements that improve patient outcomes and transform healthcare delivery.Wade began his career at Intel, where he gained valuable experience in technology development and engineering. Building on his technical expertise, he transitioned into the medical device industry, bringing a strong innovation-driven mindset to healthcare solutions.Wade is best known for his pioneering work on pacemakers, where he contributed to the design and development of advanced cardiac pacing technologies. His innovative approaches have helped improve the reliability, longevity, and patient comfort of pacemaker devices, significantly impacting the field of cardiac care.Wade received his Bachelor of Engineering (BEng), with a focus on Computer Engineering, from Iowa State University, and his MBA from University of Minnesota Carlson School of Management.#WadeDemmer #Medtronic #Pacemaker #MedicalDevice #Defibrillator #Bradycardia #CardiacResynchronization #RateAdaptivePacing #Micra #HeartRhythm #HeartFailure #Arrhythmias #ProgressPotentialAndPossibilities #IraPastor #STEM #Innovation #Technology #Science #Research #Podcast #PodcasterSupport the show

Send us Fan MailProfessor Eyal Zimlichman, MD is an internal medicine physician, a health care executive and a researcher focused on assessing and improving health care quality and value, patient engagement and patient safety.Professor Zimlichman is currently Chief Transformation, Innovation and AI Officer at Sheba Medical Center ( https://www.shebaonline.org/ ), the largest hospital system in Israel and one that is routinely listed among the top 10 on Newsweek’s list of best hospitals worldwide. Professor Zimlichman is also the Founder and Director of Sheba’s ARC ( Accelerate, Redesign, Collaborate - https://arcinnovation.org/ ) innovation program: an open global innovation ecosystem which aims to redesign healthcare through digital health solutions by 2030, focused on connecting entrepreneurs and clinicians, identifying needs, and advancing the development and deployment of new technologies from within hospital settings. Prior to these roles Professor Zimlichman has held the position of Lead Researcher at Partners Health Care Clinical Affairs Department in Boston where he was involved in the efforts to bring about a strategic care redesign initiative. Professor Zimlichman has served on several advisory committees commissioned by the Office of the National Coordinator for health information technology at the US Department of Health and Human Services and is chairing and sitting on several committees at the Israeli Health Ministry.  Professor Zimlichman is also founding member of the International Academy of Quality and Safety in Health Care ( https://isqua.org/networks/isqua-academy.html ).Professor Zimlichman is a graduate of the Harvard School of Public Health Executive Health Care Management Master of Science program and earned his MD, specializing in internal medicine, at the Technion – Israel Institute of Technology in Haifa, Israel.#EyalZimlichman #InternalMedicine #HealthcareExecutive #ShebaMedicalCenter #Israel #OpenInnovation #DigitalHealth #MedicalQualityManagement #Telemedicine #DisruptiveInnovation #TelAviv #ShebaLongevityCenter #ArtificialIntelligence #VirtualReality #Telepsychiatry #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #ViralPodcast #STEM #Innovation #Technology #Science #ResearchSupport the show

Send us Fan MailDr. Brigitte Robertson, MD ( https://www.adial.com/team/brigette-roberston-md/ ) is Chief Medical Officer of Adial Pharmaceuticals, a clinical-stage biopharma company focused on developing therapies for the treatment of addiction and related diseases, specifically Alcohol Use Disorder (AUD). In the U.S. alone, an estimated 35 million people suffer from AUD, resulting in significant health, social and financial costs. Current treatment options present significant barriers to patient adoption including abstinence and side effects which can lead to social stigmatization.Dr. Robertson has nearly 20 years of academic, clinical, and pharmaceutical industry experience. She has managed global development portfolios across multiple CNS indications, mechanisms, and in biotech, small, and large pharma. Her experience spans all phases of development, from the bench to bedside, and she has actively engaged throughout her career in advancing biomarkers to improve translation and trial outcomes (leveraging precision approaches, omics, wearables and AI). She is a scientific advisor to biotech companies, has served on industry and academic consortia and authored numerous articles published in leading peer-reviewed journals.Dr. Robertson’s industry career started at GlaxoSmithKline as a physician scientist in translational medicine for the Center for Excellence in Drug Discovery. She subsequently held senior roles in clinical development at Sepracor/Sunovion, Neurovance, Euthymics, and Shire/Takeda, where she served as VP and the Therapeutic Area Head of Neuroscience. In this last role, she led global clinical development and helped drive the disease area strategy for a large portfolio of early and late-stage assets in neurological, psychiatric, and neurodegenerative disorders, resulting in successful approvals across several indications.Dr. Robertson then served as the Chief Medical Officer of Yumanity Therapeutics, and led development of novel small molecule treatments for neurodegenerative diseases. She comes to Adial from Delix Therapeutics, where she most recently served as CMO, setting the strategy and leading clinical development for their portfolio of psychedelic-related analogs targeting the treatment of neurodegenerative disorders, and psychiatric illness including Depression, Anxiety/PTSD, and Substance use.Dr. Robertson completed residency training at the University of Colorado Health Sciences Center, followed by a fellowship in child and adolescent psychiatry and a second post-doctoral research fellowship, sponsored by the NIH in neuroimaging and psychopharmacology at the University of California in San Diego (UCSD). In addition, she has held faculty positions at CCP Children’s hospital in San Diego, USCD, and Duke University.#BrigitteRobertson #AdialPharmaceuticals #Addiction #AlcoholUseDisorder #Ondansetron #DrugRepurposing #5HT3Receptor #SingleNucleotidePolymorphisms  #ProgressPotentialAndPossibilities #IraPastor #STEM #Innovation #Technology #Science #Research #Podcast #PodcasterSupport the show

Send us Fan MailBilu Huang ( https://biluhuang.com/ ) is a visionary scientist dedicated to finding solutions to some of the most pressing challenges facing humanity. His interdisciplinary work spans multiple fields, including biological aging, dinosaur extinction theories, geoengineering for carbon removal, and controlled nuclear fusion technology.Born in Sanming City, Fujian Province, Huang is an independent researcher whose knowledge is entirely self-taught. Driven by curiosity and a relentless pursuit of scientific exploration, he has achieved numerous research results through his dedication and passion for science.As a talented theoretical gerontologist,  he proposed the Telomere DNA and ribosomal DNA co-regulation model for cell senescence (TRCS) and he is now using this latest theory to develop biotechnology to rejuvenate cells which will be used to completely cure various age-related degenerative diseases and greatly extend human life at Fuzhuang Therapeutics ( https://lab.fuzhuangtx.com/en/ ).#Aging #Longevity #BiluHuang #FuzhuangTherapeutics #TelomereDNAAndRibosomalDNACoRegulationModelForCell #Senescence #TRCS #DinosaurExtinctionResearch #CarbonRemovalTechnology #ControlledNuclearFusion #TelomereDNA #RibosomalDNA #CellularAging #GeneticProgram #Telomere #P53#ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #ViralPodcast #STEM #Innovation #Technology #Science #ResearchSupport the show

Send us Fan MailDr. Karen Knudsen, MBA, PhD, is the Chief Executive Officer of The Parker Institute for Cancer Immunotherapy ( PICI - https://www.parkerici.org/ ), a 501c3 nonprofit organization driving the next generation of cancer treatment by accelerating the development of breakthrough immune therapies to turn all cancers into curable diseases.Dr. Knudsen most recently served as the Chief Executive Officer of the American Cancer Society (ACS) and ACS Cancer Action Network (ACS CAN), where she led both organizations through a period of transformative growth, significantly expanding research investments, advocacy reach, and direct patient support initiatives. Under her leadership, ACS evolved into a unified, high-performing enterprise, increasing revenue by more than 30 percent and broadening its impact to serve over 55 million lives annually. Moreover, Dr. Knudsen developed and scaled innovative programs that included joint ventures and an impact innovation arm to accelerate progress against cancer.Prior to ACS, Dr. Knudsen served as Executive Vice President of Oncology Services at Jefferson Health and Enterprise Director of the Sidney Kimmel Comprehensive Cancer Center, growing a multi-state oncology network and spearheading advancements in translational cancer research that increased early access to the most advanced cancer care. A globally recognized expert in prostate cancer, Dr. Knudsen has authored over 200 scientific publications and generated practice-changing discoveries. Dr. Knudsen held leadership roles with organizations including the National Cancer Institute Board of Scientific Advisors, the Association of American Cancer Institutes, and the American Association for Cancer Research. She currently serves on the boards of Exai Bio, Paradigm Health, and Research!America, and advises multiple biotech ventures including ArteraAI and Transcarent.Dr. Knudsen holds numerous awards for her scientific and healthcare accomplishments, and this year will be honored with the Allen Lichter Visionary Leader Award from the American Society of Clinical Oncology (ASCO), recognizing her lifetime achievement of outstanding contributions to the field of oncology.Dr. Knudsen holds a PhD in Biological Sciences from the University of California, San Diego, and an MBA from Temple University’s Fox School of Business. She has been recognized as one of Forbes’ “50 Over 50: Women of Impact”, a CNBC Changemaker, and is a CEO Council Member for both the Wall Street Journal and CNBC.#Oncology #Immunooncology #Cancer #KarenKnudsen #ParkerInstituteForCancerImmunotherapy #AmericanCancerSociety #JeffersonHealth #UniversityOfCalifornia #LudwigInstituteForCancerResearch #UniversityOfCincinnati #ProstateCancer #CART #CellTherapy #CheckpointInhibitors #TumorAntigenDiscovery #TumorMicroenvironment #OncolyticViruses #Pluvicto #Philadelphia #CarlJune #JamesAllison #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #ViralPodcast #STEM #Innovation #Technology #Science #ResearchSupport the show