Progress, Potential, and Possibilities Podcast / Show

Send us Fan MailWhat if most dogs aren’t dying of old age - but from losing their ability to move?Dr. Laurie McCauley, DVM, DACVSMR, CCRT, CVA, CVC is a pioneer in veterinary rehabilitation and one of the most influential figures in canine sports medicine. With over two decades at the forefront of the field, she founded the first dedicated veterinary rehabilitation clinic in the United States and designed the world’s first underwater treadmill specifically for dogs - innovations that helped transform how veterinarians approach mobility, recovery, and performance in animals.A board-certified specialist in Canine Sports Medicine and Rehabilitation, Dr. McCauley has trained thousands of veterinarians, physical therapists, and rehabilitation professionals around the world, and her work has played a central role in shaping modern standards of care.Dr. McCauley is the founder and instructional director of Optimum Pet Vitality ( https://optimumpetvitality.com/ ), an education platform focused on delivering evidence-based, practical training to veterinary professionals and pet owners alike, covering areas such as therapeutic exercise, laser therapy, and fascia-based treatments.In addition, Dr. McCauley is the owner of Red Tail Rehab, where she provides personalized, in-home rehabilitation care, helping animals improve mobility, reduce pain, and enhance quality of life.Dr. McCauley’s career has been defined by a singular mission: to help animals move better, feel better, and ultimately live longer, healthier lives.#DogLongevity #PetHealth #CanineRehab #DogAging #VeterinaryMedicine #PetWellness #HealthyPets #DogHealth #LongevityScience #AnimalHealth #PetCareTips #SeniorDogs #CanineHealth #MobilityMatters #PetLongevity #VeterinaryRehabilitation #DogFitness #AgingResearch #BiohackingPets #HealthspanSupport the show

Send us Fan MailWhat if the biggest barrier in healthcare today isn’t science - but stigma?Eric Foster is Chief Commercial Officer at Ardelyx ( https://ardelyx.com/ ), a biopharmaceutical company where he leads global commercialization strategy for innovative therapies addressing high-burden gastrointestinal and cardiorenal diseases. A seasoned biotech executive with over two decades of experience, Eric has built and scaled high-performing commercial organizations across some of the industry’s most complex and competitive markets.Prior to Ardelyx, Eric held senior leadership roles at Amgen and Horizon Therapeutics, where he led rare disease and specialty business units, overseeing product launches, market access, and global growth strategy. Earlier in his career, he spent over a decade at GSK and began in commercial roles at Johnson & Johnson.Eric is known for his expertise in rare disease commercialization, payer strategy, and building first-in-class market entry plans, with a strong focus on connecting patients to therapies and reducing barriers to care. He holds an MBA in Healthcare from Auburn University and a BA in Economics from the University of Georgia.#IBSC #GutHealth #WomensHealth #HealthcareInnovation #Biotech #PharmaMarketing #LPGA #WomensSports #DigitalHealth #PatientAwareness #ChronicIllness #HealthEducation #MedicalInnovation #HealthcareMarketing #BehaviorChange #HealthStigma #ChronicDisease #Biopharma #HealthPodcast #FutureOfHealthcareSupport the show

Send us Fan MailWhat if paralysis wasn’t permanent—but just a biological system we haven’t figured out how to reboot?Dr. Lior Shaltiel, Ph.D. is Chief Executive Officer of NurExone Biologic ( https://nurexone.com/ ), a biotech company pioneering a novel exosome-based platform aimed at repairing the central nervous system.Dr. Shaltiel brings a rare combination of deep scientific training and cross-border biotech leadership. He earned his Ph.D. in molecular pharmacology from Ludwig Maximilian University of Munich, where his research focused on ion channels and retinal biology - early work that connects directly to today’s frontier in neuroregeneration.Before stepping into the CEO role, Dr. Shaltiel led R&D programs in advanced drug delivery systems, including liposome-based therapeutics, and worked in global biotech investment and partnerships. He’s also the founder of the BioMed MBA program at Hebrew University of Jerusalem, helping train the next generation of biotech leaders.At NurExone, Dr. Shaltiel is advancing the company’s ExoTherapy platform - leveraging extracellular vesicles to deliver targeted genetic payloads. Their lead program, ExoPTEN, is an intranasal exosome therapy designed to silence the PTEN gene and promote neuronal regeneration after spinal cord injury - an area where, to date, there are no approved treatments that restore lost function.#biotech #neuroscience #spinalcordinjury #regenerativemedicine #exosomes #stemcells #futureofmedicine #geneediting #biotechinnovation #medicalbreakthrough #neuroregeneration #sciencepodcast #healthtech #longevity #drugdiscovery #PTEN #RNAi #nextgenmedicine #biophysics #medtechSupport the show

Send us Fan MailWhat if we could restore vision, communicate directly with the brain, and even extend human life—not with machines alone, but with living, engineered biology?Dr. Alan Mardinly, Ph.D. is the Chief Scientific Officer and Co-Founder of Science Corp. ( https://science.xyz/ ), a neurotechnology company developing next-generation brain interfaces and biohybrid neural implants aimed at restoring human function.Dr. Mardinly leads the company’s biohybrid program, focused on combining genetically engineered cells with advanced optical hardware to create optogenetic therapies for vision restoration and new types of brain-machine interfaces.Dr. Mardinly has spent more than 15 years working at the intersection of neuroscience, genetics, and neural engineering. Dr. Mardinly earned his PhD in Neurobiology from Harvard University, where his research explored how experience and activity-dependent gene programs shape synaptic plasticity in inhibitory neurons—work that helped illuminate how neural circuits maintain stability while adapting to learning and sensory experience.Following Harvard, Dr. Mardinly conducted postdoctoral research at UC Berkeley, where he helped pioneer holographic optogenetics, a technology capable of stimulating specific neurons with extraordinary spatial and temporal precision.Dr. Mardinly later joined Neuralink, where he served as Director of Biology, leading teams focused on advancing brain-machine interface technologies. In 2021, Dr. Mardinly co-founded Science Corp., where he now works to translate cutting-edge neuroscience into therapeutic systems designed to restore vision and build the next generation of neural interfaces.#Neurotechnology  #BrainComputerInterface #Optogenetics #VisionRestoration #Biohybrid #ScienceCorp #Neuralink #FutureOfMedicine #BrainImplants #ArtificialVision #Neuroscience #Biotech #Longevity #LifeSupport #SyntheticBiology #HumanAugmentation #NextGenMedicine #DeepTech #Innovation #FutureOfHealthcareSupport the show

Send us Fan MailThere are over 9,000 rare diseases affecting 300 million people—and yet 90% of them have no approved treatment. Why?Craig Martin is the Founder and CEO of Orphan Therapeutics Accelerator ( https://www.orphantxl.com/ ), a pioneering nonprofit launched in 2024 to advance shelved therapies for ultra-rare diseases—bringing overlooked science back to life and guiding it through approval and into patients’ hands through innovative development and commercialization pathways.With more than two decades at the intersection of biotech, digital health, and healthcare strategy, Craig has built a career around unlocking value in overlooked opportunities and tackling some of medicine’s toughest challenges. He previously founded Rithm Health, where he has advised emerging biotech and health technology companies on strategy, growth, and stakeholder engagement.Craig also served as CEO of Global Genes, one of the world’s leading rare disease patient advocacy organizations, where he reversed declining revenues, launched major new initiatives, and led a successful merger with RARE-X—expanding the organization’s impact across the rare disease ecosystem.Earlier in his career, Craig spent over a decade leading Ogilvy | Feinstein Kean Healthcare, and held leadership roles at Ogilvy Consulting and Ruder Finn, advising global pharma, biotech, and health innovators.A graduate of Duke University, Craig brings a unique blend of strategic insight, policy awareness, and deep commitment to patients—focused on transforming how therapies for ultra-rare diseases are developed, financed, and delivered.#RareDisease #UltraRareDisease #Biotech #HealthcareInnovation #DrugDevelopment #GeneTherapy #OrphanDrugs #Pharma #MedicalInnovation #FutureOfMedicine #HealthTech #LifeSciences #BiotechInnovation #DrugDiscovery #PatientAccess #Healthcare #Medicine #Science #Innovation #NonprofitBiotech #RareDiseaseAwareness #GlobalHealthSupport the show

Send us Fan MailInside a fusion reactor, you’re not just creating a star—you’re building a machine that has to survive one. Temperatures hotter than the sun, relentless neutron bombardment… and materials that slowly destroy themselves from the inside out.Daniel Clark is a nuclear engineer and fusion energy expert working at the forefront of turning fusion from a scientific pursuit into a practical energy solution.Daniel is currently Director of Nuclear and Fuel Cycle Engineering at Type One Energy Group ( https://typeoneenergy.com/ ), where he leads critical efforts in breeder blanket and first wall design, as well as the tritium fuel cycle - core systems that will ultimately determine whether fusion reactors can operate sustainably at scale.Prior to joining the private sector, Daniel spent nearly eight years at the U.S. Department of Energy Office of Science, where he managed the Fusion Materials Research Portfolio. During that time, he helped launch major national initiatives, including the Material Plasma Exposure eXperiment at Oak Ridge National Laboratory, the INFUSE public-private partnership program, and the Fusion Prototypic Neutron Source.With degrees in nuclear engineering from Texas A&M University and University of Tennessee, Knoxville, Daniel brings a rare combination of deep technical expertise, federal policy insight, and commercialization experience—making him one of the key voices shaping the future of fusion energy.#FusionEnergy #NuclearFusion #CleanEnergy #FutureOfEnergy #EnergyInnovation #DeepTech #ClimateTech #Physics #NuclearEngineering #MaterialsScience #EnergyTransition #Tritium #SciencePodcast #TechPodcast #HardTech #Engineering #Innovation #FusionPower #StartupEnergy #BigScience #NextGenEnergy #AdvancedMaterials #EnergyFuture #BreakthroughScience #ClimateSolutionsSupport the show

Send us Fan MailWhat if the reason we haven’t explored deep space isn’t because we can’t… but because our engines are fundamentally too slow?Richard Dinan is Founder and CEO of Pulsar Fusion ( https://pulsarfusion.com/ ) and one of the few entrepreneurs in the world not trying to bring fusion power to Earth… but to space.While most fusion startups are focused on powering cities, Richard is building engines designed to power spacecraft—fusion propulsion systems that could dramatically cut travel times to Mars, unlock missions to Saturn’s moon Titan, and fundamentally reshape how we explore the solar system.Pulsar’s flagship efforts—including its Dual Direct Fusion Drive and the Sunbird program—aim to combine high-thrust propulsion with onboard power generation, a combination that could enable entirely new classes of deep-space missions. The company is now working with the United Kingdom Atomic Energy Authority on advanced neutron shielding and activation modeling—critical challenges for making fusion viable and safe in space.Backed by the UK Space Agency and collaborating with the European Space Agency, Pulsar is positioning itself at the center of a new space race—one where the bottleneck isn’t getting off Earth… but moving once you’re already out there.On this episode we talk about why space might be the first place fusion actually works, what it takes to build engines that can survive neutron bombardment, and whether radically faster travel could open up the outer solar system within our lifetime.#fusionenergy #spacetechnology #spaceexploration #marsmission #deepspace #futureofspace #nuclearfusion #fusionpropulsion #spacex #nasa #spaceinnovation #aerospace #futuretech #pulsarfusion #richarddinan #sciencepodcast #techpodcast #engineering #physics #spacefuture #interplanetary #spaceindustry #nextgentech #hardtech #innovation #elonmusk #spaceeconomy #ukspace #europespace #austintechSupport the show

Send us Fan MailImagine treating back pain not with surgery, not with opioids—but by using your own stem cells to repair the damage at its source.Lance Alstodt is President, CEO, and Chairman of BioRestorative Therapies, Inc. ( https://biorestorative.com/ ), a publicly traded regenerative medicine company focused on developing stem cell-based therapies to treat highly prevalent conditions, including chronic lower back pain and metabolic disorders.With more than 25 years of experience across healthcare investment banking, medical technology, and company building, Lance brings a unique perspective at the intersection of science and capital markets. Prior to joining BioRestorative, he was the founder and CEO of MedVest Consulting, advising healthcare companies on growth strategy, M&A, and capital formation.Earlier in his career, Lance held senior leadership roles at firms including Leerink Partners, Oppenheimer & Co., Bank of America Merrill Lynch, and JPMorgan Chase & Co., where he specialized in healthcare and medical technology transactions.At BioRestorative, Lance is leading the development of innovative cell therapies such as BRTX-100, an autologous mesenchymal stem cell therapy currently in Phase 2 trials for chronic lumbar disc disease, aiming to offer a non-opioid, non-surgical solution to one of the most widespread causes of disability worldwide.#StemCells #RegenerativeMedicine #BackPainRelief #Biotech #HealthcareInnovation #MedicalBreakthrough #ChronicPain #BioTech #FutureOfMedicine #StemCellTherapy #DegenerativeDiscDisease #PainManagement #HealthTech #BiotechStocks #Longevity #MedicalInnovation #CellTherapy #NonSurgicalTreatment #OpioidCrisis #SciencePodcast #HealthcareRevolutionSupport the show

Send us Fan MailWhat if we could build a fusion reactor that runs continuously—without the instability issues that have plagued the field for years?Brian Berzin is the Co-Founder and CEO of Thea Energy ( https://thea.energy/ ), a next-generation fusion company focused on advancing stellarator technology—one of the most promising but historically underexplored approaches to magnetic confinement fusion.Brian brings a unique combination of deep technical and financial expertise, with a background spanning electrical engineering, venture capital, private equity, and investment banking. Prior to founding Thea Energy, Brian served as Vice President of Strategy at General Fusion, where he helped shape commercialization strategy and led engagement with global capital markets during a pivotal period for privately funded fusion.At Thea Energy, Brian is leading efforts to “end the sun’s monopoly on fusion energy” by leveraging breakthroughs in high-temperature superconducting materials and advanced computational design to build more stable and scalable fusion systems. In 2023, the company was selected as one of a small group of awardees in the U.S. Department of Energy’s milestone-based fusion development program.Brian holds dual degrees in Electrical Engineering and Finance from Lehigh University, reflecting the interdisciplinary mindset he now applies to one of the hardest engineering challenges in the world: making fusion power a commercial reality.#fusionenergy #fusion #cleanenergy #nuclearfusion #stellarator #tokamak #science #energy #futureofenergy #deeptech #climatechange #renewableenergy #hightech #engineering #superconductors #HTS #fusionpower #energytransition #cleantech #futuretech #startup #innovation #sciencepodcast #energyindependence #decarbonization #physics #bigideasSupport the show

Send us Fan MailWe’re living through a golden age of rare disease breakthroughs—but for many patients, the hardest part begins after the drug is approved.Today we’re joined by two leaders from the multinational biopharmaceutical company UCB ( https://www.ucb.com/ ) who are helping reshape how the rare disease community thinks about what happens after a therapy is approved—because for many families, approval is just the beginning of the journey.Dr. Kim Moran, Ph.D. is Senior Vice President and Head of U.S. Rare Diseases at UCB ( https://www.ucb-usa.com/UCB-in-the-U-S/U-S-Leadership-Team/Kim-Moran ). Dr. Moran leads the company’s U.S. rare disease portfolio strategy and commercial organization, integrating clinical, regulatory, operational, and digital capabilities to bring therapies to patients with devastating and often ultra-rare conditions. Trained as a neuroscientist with a PhD from NYU and an Executive MBA from INSEAD, she has spent nearly two decades at UCB translating patient insights into real-world solutions—from epilepsy portfolio strategy to leading the recent FDA approvals and launches of two major rare disease assets. Dr. Moran is widely recognized for her leadership in the industry, including honors from the Healthcare Businesswomen’s Association and Medical Marketing + Media, and she remains deeply focused on ensuring scientific breakthroughs actually translate into meaningful impact for patients and families.Brad Chapman is Head of U.S. Epilepsy and Rare Syndromes at UCB ( https://www.ucb-usa.com/UCB-in-the-U-S/U-S-Leadership-Team/Brad-Chapman ). Mr. Chapman oversees one of the deepest portfolios of anti-seizure therapies in the industry, including BRIVIACT, NAYZILAM, and FINTEPLA, while leading nationwide teams focused on connecting patients with both treatment and support systems. Over more than 15 years with UCB, Mr. Chapman has helped pioneer new go-to-market models in neurology that move decision-making closer to patients and providers, strengthen partnerships with the epilepsy community, and rethink how pharmaceutical organizations deliver value “beyond the pill.”Together, Dr. Moran and Mr. Chapman sit at the intersection of scientific innovation, patient access, and community infrastructure, and they’re helping answer a critical question in rare disease: How do we make sure life-changing therapies actually reach—and work for—the patients who need them most?Important Episode Link - Caring for Adults with Rare Epilepsy -https://www.ucb-usa.com/sites/default/files/2024-06/UCBCAREBinder.pdf#RareDisease #UltraRareDisease #Epilepsy #CDKL5 #DravetSyndrome #RareEpilepsy #Biotech #Pharma #DrugDevelopment #PrecisionMedicine #Geroscience #HealthcareInnovation #PatientAccess #CaregiverSupport #MedicalInnovation #Neuroscience #MitochondrialDisease #TK2Deficiency #ClinicalTrials #LifeSciences #Biopharma #HealthPolicy #FutureOfMedicine #PatientCare #InnovationSupport the show