Mind & Matter

Nick Jikomes
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Jul 26, 2024 • 51min

Plant Chemistry & the Chemical Basis of Marijuana Aroma | Iain Oswald | 167

Send us Fan MailAbout the guest: Iain Oswald, PhD is an organic chemist and Director of Research & Development at Abstrax Tech.Episode summary: Nick and Dr. Oswald discuss: plant chemistry; marijuana strains and their aroma; the chemical basis of cannabis aroma; terpenes vs. non-terpene volatile organic compounds; and more.Related episodes:Marijuana, Plant Chemistry, Terpenes, Volatile Sulfur Compounds, Cannabis Industry, What Pungent Weed Smells Like & Why | Iain Oswald | #114Endocannabinoids, Stress, Exercise, Cortisol, Anxiety, Cannabis & Effects of Marijuana on Brain Development | Matthew Hill | #123*This content is never meant to serve as medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Jul 19, 2024 • 2h 10min

History of Diet & Food, Population Size & Social Stability, Psychological Pandemics, Physical & Mental Health in Civilization Cycles | Rudyard Lynch | 193

Rudyard Lynch, a history and anthropology scholar and YouTube host, dives deep into the evolution of agriculture and its impact on human society. He discusses how dietary practices shape social behavior, linking meat consumption to individualism and rice to collectivism. The conversation also explores the rise and fall of civilizations, emphasizing the connection between population density and social stability. Lynch touches on the cognitive revolution and its monumental effects on culture, creativity, and even future genetic enhancements.
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Jul 14, 2024 • 1h 29min

Evolution: Natural Selection, Genetic Drift, Origin of Life, Cellular Complexity, Epigenetics | Michael Lynch | 166

Send us Fan MailAbout the guest: Michael Lynch, PhD is an evolutionary biologist at Arizona State University who studies the origins of genomic and cellular complexity.Episode summary: Nick and Dr. Lynch discuss: natural selection vs. genetic drift; genetic mutations & the speed of evolution; origin of life; the evolution of cellular complexity; epigenetics & the inheritance of acquired characteristics; and more.Related episodes:Evolution & Animal Development: How Nature Builds & Changes Bodies | Sean B. Carroll | #138Evolution, Language, Domestication, Symbolic Cognition, AI & Large Language Models | Terrence Deacon | #141*This content is never meant to serve as medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Jul 10, 2024 • 1h 41min

PUFAs in Brain Health & Disease, Dietary Fats, Brain Lipids, Nutrition | Richard Bazinet | 165

Richard Bazinet, a neurochemist and nutritional scientist at the University of Toronto, dives into the fascinating world of brain lipid metabolism. He explores how dietary fats, especially omega-3s, impact cognitive health and function. The discussion unveils the intricate mechanics of fatty acid transport and their crucial role in neural health. Bazinet also tackles the complexities of fatty acid metabolism, emphasizing how our dietary choices can influence conditions such as fatty liver disease and neurodegenerative disorders like Alzheimer's.
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Jun 30, 2024 • 1h 48min

Seed Oils, Chronic Disease, Diet & Religious Cults, Mainstream Medicine vs. Independent Research | Tucker Goodrich | 192

Send us Fan MailAbout the guest: Tucker Goodrich is an independent researcher and self-described “seed oil zealot” who credits many of his own health improvements with minimizing his consumption of industrial seed oils. He runs a Substack page, and provides interesting commentary about scientific research on seed oils, metabolic health, and related topics.Episode summary: Nick and Tucker discuss: what seed oils are and their history; differences between omega-6 and omega-3 polyunsaturated fatty acids (PUFAs); seed oils, sunburn, and oxidative stress; Seventh Day Adventism and the relationship between religion, ideology, and diet; paleobiology of human diet; and more.*This content is never meant to serve as medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Jun 26, 2024 • 1h 9min

Dopamine, Reward, Motivation, Lateral Hypothalamus, Feeding Behavior & Eating Disorders | Melissa Sharpe | 164

Melissa Sharpe, a neuroscientist at the University of Sydney, dives into the fascinating world of dopamine and its multifaceted role in motivation beyond pleasure. She discusses the lateral hypothalamus as a key player in feeding behavior and learning associations. The conversation explores how impulsive decisions in addiction can affect long-term goals, revealing the complex interactions between brain circuits. Additionally, Sharpe shares insights from her academic journey across continents and the cultural differences in work-life balance between Australia and the U.S.
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Jun 22, 2024 • 1h 45min

Anesthesia, Placebo Effects, Consciousness, Subjectivity, MDMA, Ketamine, Opioids, Psychedelics | Boris Heifets | 163

Send us Fan MailAbout the guest: Boris Heifets, MD, PhD is an anesthesiologist and researcher at Stanford University. His lab studies non-ordinary states of consciousness and psychoactive drugs like MDMA, ketamine, and psychedelics.Episode summary: Nick and Dr. Heifets discuss: anesthesia and how anesthetics work; placebo effects & expectations in clinical research; ketamine as an antidepressant, anesthetic, and recreational drug; the subjective effects of psychedelics and other drugs; MDMA and Lykos Therapeutics’ attempts to gain FDA approval for MDMA-assisted psychotherapy; opioids & placebo effects; and more.Related episodes:How Does Ketamine Work & Is It Addictive? | Christian Lüscher | #90*This content is never meant to serve as medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Jun 16, 2024 • 1h 35min

Drugs, Addiction & Neuroplasticity: Psychedelics, MDMA, Opioids, Cocaine, Amphetamine (Adderall), Nicotine, Marijuana & Alcohol | Robert Malenka | 162

Send us Fan MailAbout the guest: Robert Malenka, MD, PhD is psychiatrist & neuroscientist. He has spent most of his career at Stanford University, where his lab studies synaptic plasticity, mechanisms of drug action in the brain, and the neural basis of behavior.Episode summary: Nick and Dr. Malenka discuss: mechanisms of synaptic plasticity in the brain, such as LTP & LTD; addiction & the dopamine reward circuitry of the brain; psychoactive drugs ranging from stimulants (cocaine, nicotine, amphetamines) to opioids (fentanyl), psychedelics, MDMA, THC, and alcohol; and more.Related episodes: How Does Ketamine Work & Is It Addictive? | Christian Lüscher | #90Neuroscience of Social Behavior, Pain, Empathy, Emotion, Brain Mechanisms of MDMA | Monique Smith | #159Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Jun 12, 2024 • 1h 33min

GLP-1, Weight Loss Drugs, Ozempic, Obesity, NMDA Receptors, Metabolism & Brain Health | Christoffer Clemmensen | 161

Send us Fan MailAbout the guest: Christoffer Clemmensen, PhD is scientist running the Metabolism & Molecular Pharmacology group at the University of Copenhagen in Denmark. His lab studies the biological basis of obesity & other metabolic disorders.Episode summary: Nick and Dr. Clemmensen discuss: GLP-1 & gut hormones; obesity & metabolic disease; GLP-1 agonists and weight loss drugs (e.g. Ozempic); novel, dual-action weight loss drugs his lab has created; and more.Previous discussion: Metabolism, Obesity & Psychedelics for Metabolic Disease | Christoffer Clemmensen | #105*This content is never meant to serve as medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts
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Jun 1, 2024 • 1h 24min

Diet, Hunting, Culture and Evolution of Paleolithic Humans & Hunter Gatherers | Eugene Morin | 160

Send us Fan MailAbout the guest: Eugene Morin, PhD is a Professor of Anthropology at the University of Trent who studies Paleolithic humans and animals.Episode summary: Nick and Dr. Morin discuss evolution of Paleolithic humans; Neanderthal diet & cultural capacity; key human adaptations related to endurance and stamina; hunter gatherer hunting strategies; evolution of human digestion; and more.*This content is never meant to serve as medical advice.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts

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