
Xiuning (Xuning) Le, MD
Clinician–scientist in thoracic oncology with expertise in molecular pathology, resistance mechanisms to EGFR TKIs, and incorporation of tissue and ctDNA testing into clinical decision-making.
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Mar 10, 2026 • 28min
S16 Ep23: Show Me the Data™: Post-TKI Sequencing in EGFR-Mutated NSCLC—Optimizing Current Strategies and Preparing for New Treatment Modalities
Xiuning Le, MD, PhD, clinician–scientist in thoracic oncology; Lyudmila Bazhenova, MD, precision medicine–focused medical oncologist; Hossein Borghaei, DO, MS, expert in systemic therapy sequencing. They discuss repeat tissue vs liquid biopsy at progression. They cover optimal NGS approaches, MET amplification detection, small‑cell transformation management, sequencing after osimertinib, bispecific antibodies, VEGF/PD‑1 strategies, and ADC considerations.


