Tom Südhof
Neuroscientist and Nobel laureate known for discovering molecular machinery of synaptic transmission; expert on how neurons convert electrical signals into rapid, calcium-triggered chemical neurotransmitter release.
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Mar 10, 2026 • 1h 30min
How Neurons Translate Electricity into Chemistry | Tom Südhof
Tom Südhof, Nobel-winning neuroscientist who uncovered the molecular machinery of synaptic transmission. He explains how action potentials trigger millisecond-fast neurotransmitter release. The conversation covers calcium-triggered vesicle fusion, the proteins that dock and prime vesicles, and how tight spatial coupling and active zone organization enable rapid signaling.
