Steven Gray

Professor of Pediatrics and co-director of the gene therapy program at UT Southwestern, specializing in AAV engineering for central nervous system delivery and translational gene therapy development.

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Feb 12, 2026 • 39min

EP 226: Scaling AAV gene therapy: Engineering delivery, safety, and cost with David Dismuke of Forge Biologics and Steven Gray of UT Southwestern

Steven Gray, a pediatric professor engineering AAVs for CNS delivery, and David Dismuke, CTO scaling GMP AAV manufacturing, discuss translating AAV from lab to industry. They cover capsid engineering for brain delivery, manufacturing workflows and analytics, full versus empty particle impacts on safety, and how scale and platform choices could cut costs and enable next‑gen gene editing.

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