Dr. Jennifer McQuade, a melanoma medical oncologist researching oncolytic therapies, and Dr. Rahul Sheth, an interventional radiologist skilled in image-guided tumor treatments, discuss intratumoral oncolytic injections like RP1. They cover how these agents work, trial evidence for refractory metastatic melanoma, practical delivery to visceral lesions, technique tips, imaging follow-up, and multidisciplinary implementation challenges and opportunities.