In this engaging discussion, Rachel Casella, a reproductive health advocate, shares her daughter’s experience with spinal muscular atrophy, emphasizing the need for genetic carrier screening. Nicola Champion, a palliative care nurse, opens up about the emotional challenges she faced while making surrogate decisions for her father. Meanwhile, Dr. Brian Earp and Dr. Teva Brenda explore the potential of AI in predicting end-of-life choices, raising intriguing questions about ethics and personal preferences in healthcare decisions.