

Paula Soteropoulos
Seasoned biotech executive and board leader with 30+ years of experience spanning Genzyme, Moderna, CEO of Akcea/Exia, Executive Chair at Ensoma, and Venture Partner at 5AM Ventures; focuses on company building, rare disease, and in vivo gene therapies.
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Sep 24, 2025 • 28min
Episode 70 - Paula Soteropoulos
In this discussion, Paula Soteropoulos, a seasoned biotech executive with over 30 years’ experience, shares her unexpected journey into the world of biotech. She delves into leadership lessons from her time at Genzyme and her role in pioneering in vivo gene therapies at Ensoma. Paula highlights the importance of mentorship, authentic leadership, and navigating funding challenges while building companies. She also reveals what makes startups attractive to investors, emphasizing validated biology and a focus on rare diseases.


