Paul Zarkowski
Consultation-liaison psychiatrist and academic who presents and interprets evidence from a meta-analysis on SSRI and anticoagulant bleeding risk, offering clinical perspective on mechanisms and prescribing implications.
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Feb 5, 2026 • 12min
The SSRI-Anticoagulant Interaction: Evidence-Based Prescribing Strategies
Paul Zarkowski, a consultation-liaison psychiatrist and academic, reviews a meta-analysis on SSRI plus anticoagulant bleeding risk. He outlines the pooled increased hazard and differences with direct oral anticoagulants. Age, sex, and baseline anticoagulant risk are discussed. Mechanisms of SSRI-related platelet effects and safer antidepressant alternatives are highlighted.
