Paola Sebastiani
Professor of Biostatistics at Tufts Clinical and Translational Science Institute and senior investigator with the New England Centenarian Study, known for analyzing genetic, proteomic, and metabolomic signatures of exceptional longevity.
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Mar 26, 2026 • 1h 2min
Born to Live Longer? Inside the Genetics and Biology of Centenarians
Paola Sebastiani, Professor of Biostatistics at Tufts who studies genetic, proteomic, and metabolomic signatures of exceptional longevity. She explains why there is no single longevity gene and why many small genetic effects matter. They cover APOE, limits of polygenic prediction, low inflammation and metabolite signals in centenarians, diet patterns, and why offspring often inherit protection.
