Natalie Exner Dean
Associate professor in biostatistics and bioinformatics at Emory University's Rollins School of Public Health, specializing in the design and evaluation of infectious disease studies and vaccine effectiveness research.
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Apr 2, 2026 • 13min
Test-Negative Study Designs for Evaluating Vaccine Effectiveness With Dr Dean
Natalie Exner Dean, PhD, associate professor of biostatistics and bioinformatics at Emory, studies infectious disease and vaccine effectiveness. She explains enrolling symptomatic people, using test-positives versus test-negatives to estimate effectiveness. She covers calculating effectiveness from odds ratios, key assumptions about disease specificity, bias reduction via healthcare-seeking restrictions, and limits from test performance and misclassification.
