Megan Kirk Chang
Senior researcher in metabolic psychiatry at the University of Oxford with a PhD in kinesiology and health sciences and extensive clinical trials experience, co-author of the DIME trial on ketogenic diet for treatment-resistant depression.
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Mar 16, 2026 • 37min
DIME Trial: New study finds a ketogenic diet may help some with severe depression
Dr. Megan Kirk Chang, a senior metabolic psychiatry researcher at Oxford with a PhD in kinesiology, co-led the DIME randomized trial testing a ketogenic versus plant-rich diet for treatment-resistant depression. She discusses trial design, why the modest keto signal matters, adherence and cravings, ketone monitoring choices, and plans for larger follow-up studies.
