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Matthew Osman
Co-founder of Polyphron and biotech entrepreneur focused on applying computational methods to recapitulate developmental biology for growing functional human tissue ex vivo.
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21 snips
Dec 17, 2025
• 2h 1min
What if we could grow human tissue by recapitulating embryogenesis? (Matthew Osman & Fabio Boniolo)
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Matthew Osman and Fabio Boniolo, co-founders of Polyphron, delve into the revolutionary concept of growing functional human tissue outside the body. They discuss the potential of recapitulating embryogenesis, aiming to repair organ damage by creating modular tissue instead of relying on full organ transplants. Topics include the challenges of current tissue engineering, the significance of 3D architecture, and the hurdles like vascularization that must be overcome for success. Their ambitious vision redefines the future of regenerative medicine.
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