In this engaging conversation, Dr. Mandy Baric, an experienced anaesthetist and educator from Melbourne, explores the intriguing world of alternative medications in anaesthesia. She highlights the importance of patients disclosing herbal use and discusses the pharmacological interactions, especially with cytochrome P450. Key topics include the risks of St John's Wort, insights on ginseng, garlic, and other 'G herbs', and practical advice for anaesthetists on managing herbal histories. Mandy’s expertise shines as she navigates these complex interactions to improve perioperative care.