Xiuning Le, MD, PhD, clinician–scientist in thoracic oncology; Lyudmila Bazhenova, MD, precision medicine–focused medical oncologist; Hossein Borghaei, DO, MS, expert in systemic therapy sequencing. They discuss repeat tissue vs liquid biopsy at progression. They cover optimal NGS approaches, MET amplification detection, small‑cell transformation management, sequencing after osimertinib, bispecific antibodies, VEGF/PD‑1 strategies, and ADC considerations.
