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Luke O'Neill

Professor of Biochemistry and Immunology at Trinity College Dublin, researcher and public commentator on inflammation, ageing and health who provides expert advice on disease prevention and lifestyle.

Top 10 podcasts with Luke O'Neill

Ranked by the Snipd community
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Feb 22, 2026 • 25min

Prof Luke O’Neill - How to get through ‘Sniper’s Alley’ and optimise your health in midlife

Prof Luke O’Neill, biochemistry and immunology professor and inflammation researcher, outlines how to fortify health in midlife. He explains the rise in risks around your 50s and shares practical tips on diet, exercise, sleep, inflammation and vaccines. Short, actionable habits and social connections are emphasized as ways to reduce long-term disease risk.
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Nov 6, 2025 • 11min

An exciting development happened in the world of immunology

Professor Luke O'Neill, a leading immunologist from Trinity College Dublin, delves into the fascinating intersection of COVID vaccines and cancer treatment. He reveals groundbreaking data showing lung cancer patients who received mRNA vaccines have doubled their survival rates. Dive into discussions about why some immune systems fail to respond and how RNA vaccines could revolutionize treatments for other diseases like malaria and HIV. O'Neill also touches on genetic sequencing of tumors to develop targeted vaccines and the potential connections between shingles vaccination and Alzheimer's risk.
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Mar 28, 2026 • 9min

Luke O’Neill on the latest developments in cancer treatment

Luke O’Neill, Professor of Biochemistry and Immunology at Trinity College Dublin, explains cutting-edge cancer advances. He describes engineered bacteria that eat tumours, how tweaks let them survive changing oxygen levels, and plans for human trials. He also covers personalised RNA vaccines guided by AI, rapid production, striking responses in pets and early human trial successes.
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Dec 4, 2025 • 7min

Immunotherapy in cancer continues to advance

In this engaging discussion, Professor Luke O'Neill, a leading biochemist from Trinity College Dublin specializing in immunology, dives into groundbreaking research on pancreatic cancer treatment. He explores engineered immune cells, specifically CAR-NKT cells, showing promise in targeting tumors effectively. O'Neill contrasts these with CAR-T approaches, discusses treatment delivery methods, and highlights preclinical successes in mice. He also addresses the projected $5,000 cost for off-the-shelf therapies and the urgency of fast-tracking human trials, sparking hope for future cancer patients.
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Nov 13, 2025 • 5min

The appetite for weight-loss drugs has been insatiable

Professor Luke O'Neill, a leading biochemist from Trinity College Dublin, dives into the booming market of GLP-1 weight-loss drugs, projected to hit $54 billion in 2024. He discusses the rapid demand growth and the safety concerns, particularly muscle loss associated with these treatments. O'Neill contrasts oral and injectable formulations, highlighting their effectiveness. Additionally, he sheds light on the broader impacts these drugs could have beyond weight loss, including potential benefits for addiction and heart health.
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Dec 24, 2025 • 9min

Will 2026 be the year of the robot?

Join Professor Luke O'Neill, a biochemistry expert from Trinity College Dublin, as he dives into the exciting world of robotics and AI. They explore the predictions that 2026 will mark a significant leap for robots in everyday life. O'Neill discusses advancements in battery technology and the capabilities of humanoid robots, alongside the global race in robotics innovation. The potential for robots in entertainment, including theme parks and immersive experiences, as well as their societal benefits, paints an optimistic picture for the future.
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Nov 27, 2025 • 10min

Science with Luke: How to avoid a hangover?

Luke O'Neill, a distinguished Professor of Biochemistry at Trinity College Dublin, dives deep into the science of hangovers. He details how compounds like acetaldehyde and dehydrating effects lead to those dreaded morning-after symptoms. Interestingly, he explains why infrequent drinkers often suffer worse hangovers and discusses the role of congeners in darker drinks. O'Neill shares practical tips like consuming milk before drinking and opting for carbohydrates and juice the next morning. His insights aim to help listeners make informed, enjoyable choices this holiday season.
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Nov 20, 2025 • 10min

Will AI actually make us less smart?

Professor Luke O'Neill, a renowned expert in biochemistry and immunology at Trinity College Dublin, delves into a thought-provoking MIT study revealing that AI may diminish students' cognitive abilities. He discusses how AI impacts creativity, attention, and the ability to defend one’s work. Luke highlights trends showing reduced critical thinking in workplaces reliant on AI. Their discussion also covers the historical fears of technology affecting cognition and suggests that while AI can aid in routine tasks, it may lead to detrimental dependence and laziness.
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Aug 28, 2025 • 12min

The demographic time bomb!

Professor Luke O'Neill, a biochemistry expert from Trinity College Dublin, dives deep into the pressing issue of declining birth rates worldwide. He highlights alarming trends in global population decline, particularly in Ireland, and discusses how education and women's empowerment play key roles in this shift. O'Neill examines the impact of technology and societal changes on family structures and the pervasive pessimism around parenthood. He raises critical questions about the future of our species and potential strategies to reverse these demographic trends.
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Feb 25, 2025 • 1h 21min

Ep. 99: “Inflammation and Innate Immunity” Featuring Dr. Luke O’Neill

Dr. Luke O’Neill, a biochemistry professor at Trinity College Dublin, dives deep into the world of inflammation and innate immunity. He explores how macrophages influence inflammatory responses and their potential role in treating nerve damage. The conversation includes exciting findings about T-cells in asthma and novel anti-inflammatory therapies being developed. O'Neill also discusses the burgeoning field of immunometabolism, where metabolism intersects with immune functionality, shedding light on future treatments for various diseases.

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