John A. Kellum
Professor and director of the Center for Critical Care Nephrology and vice chair for the Department of Critical Care Medicine at the University of Pittsburgh, specializing in critical care research including endotoxin activity and septic shock.
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Mar 4, 2026 • 38min
SCCMPod-564 CCE: Endotoxin Activity and Precision Medicine in Septic Shock
John A. Kellum, a critical care nephrology leader at the University of Pittsburgh, explains using endotoxin activity as a potential endotype in septic shock. He discusses the endotoxin activity assay, how combining it with organ failure flags a high‑risk subgroup, challenges to clinical use, and how precision medicine and targeted trials could reveal treatable sepsis subgroups.
