Javier Gonzalez-Maeso
Professor of pharmacology and toxicology at Virginia Commonwealth University specializing in G-protein coupled receptor signaling and psychedelic neurobiology, with research on sex-specific and isomer-dependent effects of MDMA and psilocybin in addiction and plasticity models.
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Feb 5, 2026 • 1h 11min
Psychedelic Neurobiology: Sex-Specific Effects of MDMA & Psilocybin in Addiction & Reward Behavior | 277
Javier Gonzalez-Maeso, PhD, a pharmacology professor studying GPCR signaling and psychedelic neurobiology. He talks about how biased agonism makes similar drugs act very differently. He explains isomers and enantiomers in MDMA and LSD. He highlights sex-specific effects of MDMA and psilocybin in animal models and implications for clinical trials and dosing.
