Dr. Lawrence Afrin
Internist and leading expert on mast cell diseases, known for clinical and research work on mast cell activation syndrome and author of Never Bet Against Ockham, with extensive publications on MCAS.
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Jan 29, 2026 • 1h 34min
Mast Cell Activation Syndrome: The Diagnosis Most Doctors Miss with Dr. Lawrence Afrin (Ep 181)
Lawrence Afrin, internist and leading mast cell disease expert, explains why mast cell activation syndrome is often missed. He discusses how MCAS can present very differently between people. Conversations cover why tryptase testing alone fails, MCAS links to neurologic and psychiatric symptoms, connections with hypermobile EDS, and emerging treatments like GLP-1 agents.
