Douglas Wallace
Geneticist and evolutionary biologist specializing in mitochondrial genetics, director of the Center for Mitochondrial and Epigenomic Medicine at Children's Hospital of Philadelphia, and a leading researcher on mitochondria in human health, aging, and evolution.
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Mar 5, 2026 • 1h 42min
Mitochondria Genetics & Human Metabolic Variation in Health & Disease | Douglas Wallace | M&M 283
Douglas Wallace, a mitochondrial geneticist and evolutionary biologist leading CHOP’s mitochondrial center, walks through mitochondria’s origins and their role in human evolution. He discusses maternal inheritance, haplogroups and climate adaptation, heteroplasmy and aging, bioenergetics in disease, ketogenic diets, cancer metabolism, and how modern mismatches affect metabolic health.
