Declan M. McLoughlin

Declan M. McLoughlin, an MD and PhD psychiatrist from Trinity College Dublin, shares insights from the KARMA-Dep2 trial on ketamine's role in treating depression. He discusses the differences between esketamine nasal spray and IV ketamine, diving into how sub-anesthetic doses can cause dissociation. The conversation explores the challenges of blinding in trials and the study’s design involving 66 participants. McLoughlin also reveals the mixed outcomes regarding ketamine's antidepressant effects compared to ECT, emphasizing the need for cautious expectations.