Bryan L. Roth
Prominent pharmacologist and receptor scientist known for solving the crystal structure of LSD bound to a serotonin receptor and developing non-hallucinogenic psychedelic analogs; recipient of DARPA funding for psychedelic-related drug discovery.
Best podcasts with Bryan L. Roth
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Apr 30, 2026 • 1h 2min
#116 Meet The World’s Greatest Psychedelic Receptor Scientist
Bryan L. Roth, a leading receptor scientist who solved LSD’s serotonin receptor structure and develops non-hallucinogenic psychedelics. He recounts his path into receptor work and the DARPA-funded hunt for therapeutic but non-trip compounds. The conversation covers kappa opioid vs serotonin mechanisms, the claustrum’s role in perception, and ultra-large virtual screens for novel drugs.
