Anastasios Karadimitris
Clinician-scientist studying invariant NKT cell biology and immunotherapy development, co-senior author of a Blood article on off-the-shelf dual CAR-iNKT cell therapy for KMT2A-rearranged leukemia.
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Feb 12, 2026 • 20min
CAR-iNKT cell immunotherapy and Jagged2/Notch regulation of HSC
Anastasios Karadimitris, a clinician-scientist developing invariant NKT cell immunotherapies, and Maria Carolina Florian, a researcher on hematopoietic stem cell aging, discuss cutting-edge science. They cover off-the-shelf dual CAR-iNKT cells targeting CD19 and CD133 and how Jagged2/Notch signaling flips from trans-activation to cis-inhibition to drive HSC aging. Short, focused conversations on therapy design and stem cell niche mechanisms.
