Amita Sehgal
Neuroscientist and chronobiologist at the University of Pennsylvania and HHMI Investigator who studies circadian rhythms and sleep mechanisms using Drosophila genetics, focusing on metabolism, mitochondria, and oxidative stress.
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Mar 29, 2026 • 1h 9min
Sleep, Brain Fat & Oxidative Stress | Amita Sehgal | 286
Amita Sehgal, neuroscientist and chronobiologist studying sleep with fruit fly genetics, explores why animals sleep. She discusses how waking creates oxidized lipids that move from neurons to glia and are cleared during sleep. Immune-like cells dock to the brain to remove lipid waste. Topics include mitochondrial protection, peroxisomes, lipid transfer via apolipoproteins, and differences between sickness and normal sleep.
