Adam Brufsky

Medical oncologist at UPMC Hillman Cancer Center with expertise in breast cancer therapeutics and clinical trials, providing commentary on CDK4/6 inhibitor selection, dosing, and toxicity management.

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Nov 24, 2025 • 24min

Challenging Cases in Breast Cancer with CDK 4/6 Inhibitors – Drs. Sara Tolaney & Adam Brufsky

Dr. Sara Tolaney, a breast cancer researcher at Dana-Farber, and Dr. Adam Brufsky from UPMC Hillman, dive into the latest advancements in CDK4/6 inhibitors. They discuss key trial updates, recommending abemaciclib for high-risk patients and exploring dosing strategies to manage side effects like diarrhea and neutropenia. Insights on tailoring treatment for metastatic cases and considering patient comorbidities highlight the importance of individualized care. Expect expert opinions on navigating the complexities of breast cancer therapeutics!

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