Best Primobolan Cycle? Advice Before Starting Gear, Thoughts On T3 & Clen, Metformin Lowers IGF-1?

Jan 9, 2026

Dive into the intriguing debate over berberine versus metformin and their impacts on health. Discover the truth about 19-nors and prolactin before exploring when Primobolan truly shines in your cycle. Big Paul provides insights on managing estrogen levels and tackling rebound strategies after a break. Learn about sodium-potassium balance and its effect on water retention, then weigh the pros and cons of T3 and Clen for fat loss. Finally, find out the best back exercises for sensitive lifters.

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ADVICE

Primobolan Works At Moderate Doses

You don't need 600 mg/wk to get benefit from Primobolan; lower doses still modulate estrogen and SHBG positively.
Use Primo as an anabolic to improve testosterone's effectiveness rather than defaulting to an aromatase inhibitor.

ADVICE

Manage High E2 With Primo Instead Of AI

If TRT causes high estradiol, prefer adding low-dose Primo over routine AI use to manage E2 and boost free testosterone.
For ~100 mg/wk TRT consider 50–75 mg Primo; for ~200 mg/wk consider ~100 mg Primo.

ADVICE

Treat Short Holiday Downshift As A Cruise

If you drop to 250 mg/wk during a rebound holiday, treat it as a cruise and resume a cleaner diet and training.
Give six more weeks on cruise before starting a mass/off-season push rather than immediately resuming the rebound.

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Welcome back to another Anabolic Q&A—where we break down real questions from lifters about bodybuilding progress, staying healthy, managing side effects, and making smarter decisions instead of doing the “stupid stuff” that wrecks bloodwork, performance, and long-term results.

In this episode, Big Paul covers the topics people actually argue about in the gym and online: berberine vs metformin, the truth about 19-nors and prolactin, when Primobolan starts to “shine,” how to think about estrogen management, what happens when you go off the rails during a rebound, water retention + sodium/potassium balance, and more.00:00 - Intro
01:30 - Berberine Vs. Metformin
07:09 - Do 19-Nors Raise Prolactin?
13:48 - At What Doses Does Primo Start To “Shine”?
18:07 - How To Manage Estrogen If You’re A High Converter
20:23 - Should You Continue A Rebound If You Went Off The Rails For 2 Weeks?
22:57 - How To Manage Peripheral Neuropathy In Two Fingers
27:18 - How Much Sodium Should We Consume?
33:32 - Can Metformin Blunt HGH Conversion To IGF-1?
37:05 - Can A Carb Cycling Diet Be Used During Maintenance?
40:12 - Best Back Exercises For Someone Who Can’t Do Bent-Over Movements
42:51 - Advice Before Starting Gear
45:33 - Can Higher Doses Of T3 & Clen Cause Fatigue & Aches?
48:50 - Wrapping Up!

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