The Primal Podcast Ep 154 - Dr D'Agostino | #1 Way To Double Autophagy & Lose Weight [EAT THIS]
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Apr 5, 2026 Dr. Dom D'Agostino, neuroscientist and metabolic researcher known for ketogenic diets and performance work with NASA and the DoD. He explains insulin as the key metabolic marker. He introduces sardine fasting as a protein-sparing way to trigger autophagy. He discusses ketosis for gut integrity, brain protection, cancer research, and practical tips like MCTs and top nutrient-dense foods.
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Track Labs Not Just Weight During Keto
- Do monitor biomarkers (insulin, glucose, ketones, HSCRP, ApoB) when using ketogenic strategies and adjust clinically.
- Dom measured insulin at 1.9 after sardine fasting and used ezetimibe to manage genetically high LDL/ApoB while tracking vascular scans.
Ketosis Supports Gut Mucus And Barrier Integrity
- Ketosis can shift the gut microbiome toward protective species like Akkermansia that strengthen the mucosal lining.
- Dom links increased Akkermansia on keto to improved gut barrier integrity and reduced intestinal permeability.
Fred Hatfield's Remission After Sardine Cycles
- Dom recounts advising Dr. Fred Hatfield, who used ketogenic cycles and sardine fasting and entered rapid remission from metastatic prostate cancer.
- He stresses this is not a universal cure but illustrates ketone vulnerability in some cancers.
