S5E08. Longevity and GLP-1s: What Actually Works and What Doesn’t with Dr Sebastian Pedersen

Mar 30, 2026

41:11

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Longevity is trending.

But most people are still overlooking what actually drives it.

At the same time, GLP-1s and peptides are on the rise. Powerful tools, but often used without the structure or understanding required to make them effective.

In this episode, I’m joined by Dr Sebastian Pedersen to break down what actually works.

We cover the fundamentals of longevity, where GLP-1s fit, and what you need to have in place if you’re thinking about using them.

Because this is not just about weight loss.

It’s about long-term health, performance, and staying at the top

In this episode, Dr Sebastian covers

The key drivers of longevity and healthspan
Why VO2 max and strength matter more than most people realise
What peptides and GLP-1s are and how they work
Who GLP-1s are actually for and where they are being overused
The risk of muscle and bone loss with weight-focused approaches
Why behaviour change still underpins everything
What an effective exit strategy looks like

Key Quotes

“GLP-1s are a tool. Not the solution.”

“If you are not protecting muscle and bone, you are trading short-term outcomes for long-term problems.”

“This is not about a replacement for sleep because nothing replaces sleep, but it is a possible support tool when you are under more load than usual.”

Timestamps

(00:00) – Why longevity is misunderstood and the rise of shortcuts

(02:30) – Dr Sebastian’s story and shift to preventative health

(07:30) – The core pillars that actually drive longevity

(10:00) – VO2 max, strength and what the data tells us

(13:00) – What peptides are and why they’re trending

(17:00) – Regulation, safety and the reality in Australia

(19:00) – What GLP-1s are and how they work

(23:00) – Who GLP-1s are for and where they are being overused

(27:00) – The risk to muscle, bone and long-term health

(30:00) – Exit strategies and why most people get this wrong

(33:00) – The ideal conditions if you are going to use GLP-1s