Razib Khan's Unsupervised Learning

Chris Masterjohn: COVID-19 to mitochondrial health, communicating and applying "the science"

Mar 30, 2026
Chris Masterjohn, nutritional scientist and mitochondrial biology expert who founded Mitome, explains why cellular energy matters. He recounts clashes over COVID messaging and social media, outlines a mitochondria-first approach to health, and describes personalized mitochondrial testing, altitude and light therapies, and why diet and lifestyle often deserve priority over quick pharmaceutical fixes.
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INSIGHT

Mitochondria Are The Primary Driver Of Whole-Body Health

  • Mitochondria produce roughly 90% of cellular energy and control maintenance, repair, and distribution across the body.
  • Chris Masterjohn links a linear decline in mitochondrial function from ~age 18 to aging outcomes, with ~75% variability driven by lifestyle not age.
ANECDOTE

Early COVID Infection Shaped Masterjohn's Public Stance

  • Chris described getting COVID early and deciding natural immunity made vaccination unnecessary for him at that time.
  • He recounted social media pushback and near-YouTube ban when sharing studies and alternative treatment data like arginine.
ADVICE

Test Mitochondrial Function Before Chasing Fixes

  • Prioritize mitochondrial health as the first approach to broad health goals because energy availability controls repair and function.
  • Test mitochondrial function with Mitome to find individual bottlenecks and then tailor foods, supplements, exercise, and tech accordingly.
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