Being Well with Forrest Hanson and Dr. Rick Hanson

Psychedelic-Assisted Therapy with Dr. Albert Garcia Romeu

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Aug 15, 2022
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INSIGHT

Psychedelics Can Reboot Maladaptive Brain Patterns

  • Psychedelics appear to disrupt entrenched patterns by altering brain dynamics and enabling a post-experience 'reboot' where dysfunctional patterns are blunted.
  • That plastic window, paired with therapeutic support, increases chances a person will form healthier behaviors and perspectives.
INSIGHT

Cellular Growth and Network Shifts Underlie Lasting Effects

  • Imaging and animal work show psychedelics spur synaptogenesis and change network connectivity, notably affecting default mode network hubs, thalamus, amygdala, prefrontal cortex and hippocampus.
  • These cellular and network changes correlate with reduced amygdala reactivity and longer-term reductions in depression and anxiety in some studies.
INSIGHT

Both Brain Mechanisms And The Trip Matter For Therapy

  • Therapeutic benefit likely needs both biological effects and the subjective experience; some conditions might benefit from non-hallucinogenic doses but psychiatric change often requires the experiential component.
  • Blocking the subjective experience (e.g., via receptor blockade) may eliminate key therapeutic effects for mental health conditions.
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