The World, the Universe and Us The evolutionary price we pay for longer lives; the asteroid coming VERY close to Earth; how dinosaurs shaped the ecosystem
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Sep 19, 2025 In this engaging discussion, guest Alex Wilkins, a science journalist specializing in astronomy, dives into the evolutionary trade-offs we face for longevity, particularly the double-edged sword of inflammation. He explains how our immune system promotes longer lives but can lead to chronic health issues. The conversation shifts to the asteroid Apophis, set to pass close to Earth in 2029, exploring its significance for planetary defense. Lastly, Alex reveals how dinosaurs were ecosystem engineers, reshaping landscapes and rivers long before their extinction.
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Priming Enhances Response And Risk
- Having many death-fold proteins primes immune cells for fast decisions but increases spontaneous self-destruction risk.
- These spontaneous crystallisations could drive chronic inflammation as we age.
Be Cautious With Anti-Inflammatory Strategies
- Targeting senescent cells or blocking accidental immune self-destructs could reduce inflammaging.
- But weigh benefits carefully because dampening cell death may raise infection or cancer risks.
Practical Steps To Reduce Inflammaging
- Nurture gut microbes with a long-term high-fibre, plant-rich Mediterranean diet to lower inflammation.
- Exercise regularly, including strength and balance training, to reduce mortality and dampen inflammation.
