BETTER! Building bodies women can trust with Dr. Stephanie Estima

What’s Really Causing Women’s Hair to Thin & How To Reverse It with Alessandra Zonari PhD

Jun 16, 2025

Alessandra Zonari, Co-founder and CSO of OneSkin, specializes in stem cell biology and skin regeneration. She dives into the science of hair loss, detailing how hormonal changes and inflammation affect women differently than men. Discover groundbreaking peptides like OS1 and their potential to enhance hair follicle health. Alessandra shares practical advice on using hair care products, the benefits of red light therapy, and the importance of a healthy scalp for vibrant hair. Tune in for a blend of science and actionable insights!

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ADVICE

Recognize Normal Hair Shedding

Normal hair shedding is about 100 hairs per day, varying by hair length.
Notice increased shedding or stress, diet changes as possible causes requiring attention.

INSIGHT

Inflammation Shrinks Growth Phase

Scalp inflammation and senescent 'zombie' cells shorten hair growth phase.
Maintaining a healthy scalp environment prolongs hair growth and thickness.

INSIGHT

Zombie Cells Cause Hair Thinning

Senescent cells around hair follicles cause inflammation and disrupt hair production.
Targeting these cells can lessen hair thinning and improve follicle health.

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Alessandra Zonari PhD, co-founder of OneSkin, began her career in stem cell biology after witnessing her grandparents’ struggles with age-related diseases. She shares the science behind hair loss in men and women, the impact of hormonal changes, inflammation, and senescent cells on hair health, and the distinct patterns of hair loss between genders. Dr. Zonari also compares the effectiveness of Minoxidil to natural alternatives like OS1 peptide and provides practical advice on using these products for optimal results. Tune in to gain insights into hair loss prevention and create a healthier scalp for youthful, vibrant hair.

Episode Overview (timestamps are approximate):
(00:00) - Hair Loss Prevention and Treatment
(05:00) - Understanding Hair Loss in Women
(20:00) - Hair Loss Prevention Strategies
(27:00) - Hair Loss Solutions & Side Effects
(38:00) - Hair Growth and Scalp Health
(47:00) - Basic Hair Care
(56:00) - BONUS! Dr. Stephanie's “After-Party” Wrap-Up Comments

Resources mentioned in this episode can be found at https://drstephanieestima.com/podcasts/ep421/

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