Buprenorphine: The Most Misunderstood Medication of the Century | Pain Pod

Can anyone truly explain the dynamic comprehensive pharmacology of buprenorphine in 30 minutes or less? This isn’t pizza delivery folks, its pharmacology, brought to you by the Pain GuyTM! In this episode of the Pain Pod, we’ll run down the recent MAT/MATE Acts in respect to the elimination of the X-Waiver, and then dive into the pharmacological phun of buprenorphine including its synthesis, mechanisms of action, Mu receptor affinity, metabolism (half-life), max daily dose, induction/micro dosing, MME factor, ceiling effect, side effects, mcg vs mg approvals, misuse, diversion, abuse, costs, and access. Can it be done in less than a half hour? You betcha! Join Mark “Pain Guy” Garofoli on this episode of the Pain Pod. Come one, come all, to the Pain Pod!!!

DEA Letter • https://www.deadiversion.usdoj.gov/pubs/docs/A-23-0020-Dear-Registrant-Letter-Signed.pdf

MAT/MATE Acts (Presidential Ink) • https://www.pewtrusts.org/en/research-and-analysis/articles/2022/12/30/president-signs-bipartisan-measure-to-improve-addiction-treatment

Buprenorphine Pain Management Products Narrative Review • Hale M, Garofoli MP, Raffa R. Benefit-Risk Analysis of Buprenorphine for Pain Management. Journal of Pain Research. 24 May 2021 Volume 2021: 14 Pages 1359-1369.