
The Undifferentiated Medical Student Ep 014 - Infectious Diseases with Dr. Robert Kalayjian
Dec 30, 2016
Dr. Robert Kalayjian, Director of Infectious Diseases and HIV/TB researcher and teacher. He discusses why he chose infectious disease, a typical week balancing clinics, inpatient consults, research and teaching. He describes memorable diagnostic puzzles, public hospital realities, evolving diagnostics and drug pipelines, and advice for students exploring the field.
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Molecular Tests And Sicker Outpatients Will Reshape ID
- Molecular diagnostics and outpatient management of sicker patients will reshape ID over 10–20 years.
- Kalayjian predicts culture-based methods will be supplanted by molecular tests while more patients receive IV therapy and complex care at home.
Antibacterial Pipeline Is Slowing While Resistance Grows
- Antibiotic development lags while antivirals have expanded, leaving multidrug resistance as a major concern.
- Kalayjian notes a slowdown in antibacterial pipelines but progress in antivirals and new drugs for multidrug-resistant TB and bacteria.
Public Hospital Care Requires Extra Follow Up
- Working in a public hospital means patients often present later and lack primary care, so ID clinicians must provide more follow-up and care coordination.
- Kalayjian explains MetroHealth patients present with advanced disease and require extra outpatient management.




