
LessWrong (30+ Karma) “Slack in Cells, Slack in Brains” by Mateusz Bagiński
Mar 31, 2026
Mateusz Bagiński, a writer and LessWrong contributor who studies biological and cognitive tradeoffs, explores why maintaining slack matters. He links how cells and brains preserve free capacity to flexible planning. Short scenes cover bacterial size tricks, large-cell adaptations, how slack erodes through tiny choices, and why defaulting to extra slack helps.
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Free Cell Volume Is Selected For Flexibility
- Biological systems favor cell sizes that maximize free cytoplasmic volume as slack for adaptability and robustness.
- Kempes et al. data show ribosomes/RNA scale faster with size while DNA/membrane do not, creating an optimal mid-range with maximal free volume.
Extreme Cell Sizes Cheat Constraints
- Cells at extreme sizes stretch constraints by changing body plans, e.g., tiny cells thin membranes and shrink genomes, huge bacteria use vacuoles to reduce maintenance load.
- Examples include tiny spherical bacteria minimizing membrane fraction and Thiomargarita namibiensis filling >90% volume with vacuoles.
Slack Means Room To Buffer And Adapt
- Slack is defined as absence of binding constraints that lets cells adapt and buffer toxic buildup, linking free volume to robustness.
- Lower free cell volume makes concentrations more sensitive to molecule-number changes, reducing robustness to perturbations.
