The Dr. Tyna Show

Weight Regain After GLP1s & Why It's Expected | Solo

Jan 16, 2026
The discussion uncovers why weight regain often follows the cessation of GLP-1 medications. It emphasizes that these drugs treat chronic conditions rather than cure them. The host warns that high doses without lifestyle changes can lead to severe complications. Key insights highlight the influence of genetics, the role of strength training, and the potential of natural alternatives like CaloCurb. The podcast provides practical advice for managing weight post-medication, emphasizing the need for a holistic approach to metabolic health.
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INSIGHT

High Doses Can Break The Hormone Orchestra

  • High-dose GLP-1s can disrupt multiple hormonal systems and the 'orchestra' of appetite signals.
  • Overly aggressive dosing risks GI issues, metabolic brittleness, and shutdown of endogenous signaling.
ANECDOTE

Family Experience Shaped Her View

  • Dr. Tyna Moore describes growing up in an obese family and being the only one who maintained stable weight.
  • That experience shaped her understanding that sustained weight maintenance is intentional and challenging.
INSIGHT

Meta-Analysis Quantifies Typical Regain

  • The meta-analysis found average regain of ~0.4 kg/month and return to baseline ~1.7 years after stopping medications.
  • Newer agents (semaglutide/terzepatide) had faster regain (~0.8 kg/month) and quicker return.
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