JACC This Week November 11, 2025: Precision, Place, and the Future of Cardiovascular Prediction | JACC This Week
Nov 3, 2025
Explore the intriguing intersection of geography and cardiovascular risk as the discussion challenges standard models. Discover insights from the OCEAN Mitral study on heart repair outcomes and the strong link between placental malperfusion and congenital heart disease. Learn about innovations in risk assessment with high-sensitivity troponin testing and the implications of blood group classifications in COVID-19. Finally, gain perspective on the human side of pediatric cardiology and the future of translational science from its new editor.
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The Geography Gap In Risk Prediction
- Risk models that ignore place produce miscalibrated predictions across geographies.
- Harlan Krumholz argues we must recalibrate models locally and make geographic variation explicit.
Mitral Gradients Predict Post-Repair Risk
- Post-procedural transmitral gradient predicts outcomes after transcatheter edge-to-edge mitral repair.
- Each 1 mmHg higher mean gradient associated with ~10% higher risk of death or heart-failure hospitalization.
Placenta And Heart Share Developmental Pathways
- Placental malperfusion often co-occurs with congenital heart disease and links to worse neonatal outcomes.
- De novo variants in placental and cardiac developmental pathways suggest shared developmental mechanisms.