Desmoid Tumors | Oncology Today with Dr Neil Love: Management of Desmoid Tumors

Featuring perspectives from Dr Mrinal Gounder, including the following topics:

• Incidence and prevalence of desmoid tumors (00:00)

• Outcomes associated with historical management paradigms for desmoid tumors (17:15)

• Rationale for targeting the gamma secretase complex and Notch pathway as a therapeutic approach for desmoid tumors; mechanism of action of nirogacestat (20:56)

• Key efficacy outcomes from the Phase III DeFi trial evaluating the gamma secretase inhibitor nirogacestat versus placebo for progressing desmoid tumors (30:14)

• Spectrum and frequency of adverse events, including ovarian dysfunction, with nirogacestat (36:06)

CME information and select publications