The Neuro Experience

The FDA Just Removed a 22-Year-Old Warning | ft. Dr. Mary Claire Haver

Nov 18, 2025
Dr. Mary Claire Haver, a renowned OB/GYN and menopause specialist, challenges common misconceptions about menopause. She discusses the FDA's recent removal of the black box warning on hormone therapy, which aims to reduce fear and encourage use. Dr. Haver also tackles the importance of lifestyle changes, such as strength training and sleep, over trendy biohacks. She reveals insights on mental health during menopause and the significance of informed care, emphasizing that menopause is not a disease, but a natural transition.
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ANECDOTE

'Whiny Woman' Teaching Moment

  • Mary Claire Haver recounts being taught that women 'somaticize' psychological issues and calling a patient a 'whiny woman'.
  • That mindset delayed recognizing perimenopause and left clinicians unprepared.
INSIGHT

Antidepressant Use Climbs In Midlife

  • Antidepressant use rises across midlife: ~10% premenopause, ~20% during transition, ~25% by 65.
  • Hormonal changes are often overlooked as contributors to mental health symptoms.
INSIGHT

Timing Matters For HRT Benefits

  • The timing (critical window) matters: WHI stratified results showed benefits when HRT starts before 60 or within 10 years of menopause.
  • Modern RCTs with estradiol/progesterone in younger women are still needed but unlikely without major funding.
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