Huberman Lab

The Biology of Slowing & Reversing Aging | Dr. David Sinclair

984 snips
Dec 27, 2021
Guest
David Sinclair
In this engaging discussion, Dr. David Sinclair, a tenured Professor of Genetics at Harvard and a leading expert in longevity, reveals groundbreaking insights into aging. He explores how fasting, specific supplements like NMN and metformin, and lifestyle choices can potentially reverse aging. Sinclair emphasizes the importance of monitoring key blood markers to distinguish biological from chronological age. He also discusses the hidden dangers of excess iron and how novel research may provide future breakthroughs in longevity and health optimization.
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ADVICE

Metformin and Exercise

  • Metformin, a diabetes drug, mimics low energy and is beneficial for longevity.
  • Skip metformin on exercise days if you want to maximize muscle growth and minimize inflammation.
ADVICE

Resveratrol Supplementation

  • Red wine contains resveratrol, but you'd need 200 glasses daily for an effective dose.
  • Take 1,000mg of pure, light-colored resveratrol supplement daily with a fatty substance.
ADVICE

NMN Supplementation

  • Take 1,000mg of NMN daily to boost NAD levels, which decline with age and obesity.
  • NMN is a better precursor to NAD than NR or vitamin B3, as shown in mouse studies.
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