FantasyPros - Fantasy Football Podcast

Best NFL Prop Bets For Week 16 (Ep. 1912)

Dec 20, 2025
Discover expert prop bets for Week 16 as the hosts dive into standout players. Amon-Ra St. Brown's over on receiving yards is highlighted alongside Ladd McConkey's promising matchup. Expect Nico Collins to shine against the Raiders and De'Von Achane to thrive in his safety-net role. Jacoby Brissett is predicted to surpass his passing yards with a struggling defense ahead. The duo also shares touchdown picks, featuring Mike Evans and Travis Kelce, making this a can't-miss guide for your betting needs!
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ADVICE

Pick The Primary Target In Shootout Spots

  • Play Nico Collins over 61.5 receiving yards since he's the Texans' primary target and has cleared this mark repeatedly.
  • Assume the Texans will need passing yards even if the game skews toward a blowout.
ADVICE

Target RBs As Safety-Valves With Rookie QBs

  • Expect Quinn Ewers to use Devon Achane as a safety-valve and bet Achane over 27.5 receiving yards.
  • Favor rookie QB dump-offs to backs when the opponent ranks poorly defending RB receiving.
ADVICE

Exploit Week-Ending Defensive Layoffs

  • Ride Jacoby Brissett over 243.5 passing yards in a game where both defenses lack motivation and have played poorly.
  • Use games with low stakes for defenses as fertile spots for QB yardage overs.
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