Kwik Brain with Jim Kwik Harvard Doctor: The Hidden Reason Behind Low Energy, Aging, and Cognitive Decline (And How to Fix It)
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Mar 9, 2026 
Dr. Andrew Salzman, a Harvard-trained physician and longevity researcher, explains why cellular fuel loss drives low energy and brain fog. He discusses NAD’s central role in cellular energy, how NMN can replenish it, the “bathtub” model of production versus depletion, inflammation’s role via CD38, and practical ways to preserve cellular energy.
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NAD Is The Cell’s Master Fuel
- NAD is a central cellular molecule involved in ~500 reactions that powers energy, cognition, stress response, and longevity.
- By age 50 you have roughly half the NAD you had at 20, which directly reduces cellular “fuel” and slows brain and body performance.
Boost And Protect NAD Levels
- Treat cellular NAD like a bathtub: increase production (spigot) and reduce depletion (drain) to raise steady-state levels.
- Boost with precursors like NMN and also target mechanisms that destroy NAD for lasting effect.
Avoid Inflammation To Stop NAD Drain
- Avoid chronic inflammation to preserve NAD because inflammation raises the enzyme CD38 that cleaves NAD.
- Maintain exercise, good diet, and infection prevention to keep CD38 activity lower and sustain NAD.