Your Longevity Blueprint 241: The Hormone Dysfunction Epidemic: What GLP-1 Drugs Reveal About Metabolic Health Part 1
What if the explosion of GLP-1 drugs like Ozempic and Wegovy is not a weight loss revolution, but rather a warning sign that something in our metabolic health is fundamentally broken?
Today, we take a deep dive into the lesser-known satiety hormones, such as CCK and PYY, exploring how dysfunction in these hormones could be silently accelerating your aging and sabotaging your health span.
I’m excited to welcome Ashley Koff, a registered dietitian with more than 25 years of experience in functional and integrative nutrition, for a two-part series. In Part 1 today, we break down why your satiety hormones may be underperforming, how this links to aging and longevity, and simple strategies you can start using today to support metabolic health naturally.
How to support your weight-health hormones:
- Focus on supporting your digestion first, rather than jumping straight into weight loss or metabolic fixes
- Ensure you’re consuming enough protein and amino acids to support peptide hormone production
- Reduce gut irritants like alcohol, ultra-processed ingredients, and unnecessary fasting
- Nourish your body consistently, especially during times of hormonal change, instead of restricting
- View digestive symptoms as signs of dysfunction instead of problems to push through or ignore
Bio: Ashley Koff
Ashley Koff is a registered dietician and who is the founder of the Better Nutrition Program (BNP), the nutrition course director for UC Irvine’s Susan Samueli Integrative Health Institute’s Integrative and Functional Medicine Fellowship, and a faculty member at the Integrative and Functional Nutrition Academy (IFNA), where she teaches “An Integrative and Functional Nutrition Approach to Obesity and Weight Management.”
She is also the author of the upcoming book Your Best Shot (HarperOne, Jan. 6, 2026). A practitioner for more than 25 years, Koff is leading a transformative movement in personalized nutrition, turning “better, not perfect” choices into practical, sustainable strategies that deliver real health outcomes. Through patient stories and personal experience, she shows that optimal health is not just possible — it’s essential to living your fullest life. Koff has been recognized as one of CNN’s Top 100 Health Makers, featured in InStyle as “Hollywood’s Leading Dietitian,” and selected as Westin’s global nutrition ambassador.
In this episode:
- How separating weight from health leads to unhealthy behavior and long-term metabolic dysfunction
- Why a balanced approach is essential when using GLP-1 agonists and other interventions
- The importance of viewing digestive distress as an early warning sign, not a side effect to ignore
- How short-term diet “wins” can feel hopeful, yet fail to solve the underlying issue
- How metabolic health data points to a larger issue than most people realize
- The role weight-regulating hormones play beyond hunger and blood sugar
- Why supporting your weight health is foundational to your longevity
Links and Resources:
Guest Social Media Links:
Ashley Koff on Instagram
Relative Links for This Show:
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