Harvard Thinking Young people are facing increased cancer risk. Why?
Oct 8, 2025
Tomotaka Ugai, an epidemiologist tracking international cancer trends; Kimmie Ng, an oncologist leading care for younger colorectal patients; and Tim Rebbeck, a cancer prevention researcher on global disparities. They discuss rising early-onset cancer types and birth cohort patterns. They explore obesity, lifestyle, environmental exposures, genetics, screening trade-offs, and practical prevention priorities.
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Birth-Cohort Pattern Points To Generational Causes
- Early-onset cancer increases show a generational, birth-cohort pattern rather than a sudden spike.
- That pattern implies environmental or lifestyle exposures changing across generations are likely driving the rise.
A Center For Young-Onset Colorectal Cancer
- Kimmie Ng described starting a Young Onset Colorectal Cancer Center to address unique needs of younger patients.
- She highlighted fertility, sexual health, career, and parenting challenges faced by young patients diagnosed with advanced disease.
Obesity Fits Trends But Isn't The Whole Story
- Obesity matches many features of the rising early-onset cancer trend: it's global, increased in recent decades, and affects men and women.
- However, clinicians like Kimmie Ng report many young patients are not obese, so obesity can't explain all cases.