The Optispan Podcast with Matt Kaeberlein Longevity Doctors Rank the Most Hyped Supplements (AMA with Dr. Kaeberlein and Dr. Byrne)
5 snips
Apr 3, 2026 Nicki Byrne, clinical director and practicing clinician offering evidence-based perspectives on supplements and drug interactions. She and Matt tackle CoQ10 and statin muscle pain, taurine and creatine use, vitamin D and K2 targets, sulforaphane hype, fish oil omega index, lithium dosing issues, and why many supplement trials and influencer claims mislead.
AI Snips
Chapters
Transcript
Episode notes
Aim For Midrange Vitamin D And Test Slowly
- Target 50–80 ng/mL for 25(OH)D and aim for ~60 ng/mL personally, adjusting dose and retesting after months.
- Reference ranges are population-based and not optimal targets; vitamin D steady state takes months to change.
Vitamin K2 Supports Bone And May Prevent Vascular Calcification
- Vitamin K2 likely aids bone mineralization and may reduce vascular calcification, supporting combined D and K2 use.
- Epidemiology links higher dietary K2 to lower coronary disease, but clinical trial evidence is limited.
Eat Broccoli Or Use Glucoraphanin+Myrosinase Supplements
- Prefer eating broccoli/sprouts over most sulforaphane supplements; if supplementing, choose glucoraphanin plus myrosinase formulas like Avmacol.
- Sulforaphane is unstable, requires myrosinase conversion, and most branded supplements lack active ingredient.