The a16z Show

Why America’s Health Crisis Is an Incentive Problem

202 snips
Feb 4, 2026
Justin Mares, founder and CEO of TrueMed and entrepreneur focused on food and lifestyle interventions, discusses how US food policy and modern environments drive poor health. He covers crop subsidies, grocery-as-healthcare ideas, using HSA/FSA dollars for prevention, psychedelics and peptides as therapies, and treating chronic disease as a national security issue.
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Processed Food Shift Began In The 1970s

  • American food companies replaced real ingredients with ultra-processed substitutes over decades, starting in the 1970s.
  • This shift produced addictive, nutrient-poor foods that contributed to rising obesity and chronic disease.

Fix Crop Subsidies To Change Diets

  • Fix crop subsidies that make corn, soy, and wheat artificially cheap to change ingredient incentives.
  • Redirecting subsidies would reduce soybean oil and HFCS prevalence in packaged foods.

Pay For Prevention, Not Just Treatment

  • Treat lifestyle interventions (exercise, diet, sleep) as healthcare and fund them through insurers and HSAs.
  • Build infrastructure to make prevention financially accessible and incentivized.
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