This Week in Virology TWiV 1253: Harvard virology is not retreating
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Sep 14, 2025 In this lively discussion, Aaron Schmidt, head of Harvard's virology program, shares his insights on using protein engineering to modulate immune responses against viruses like influenza. Tatum Sass reflects on her CAR T cell advancements, while Ben Gewurz unpacks the complexities of Epstein-Barr virus and its ties to health issues. They emphasize resilience in research and the need for clear science communication, all set against the backdrop of the Harvard virology retreat, which celebrates collaboration and the importance of mentorship in shaping future scientists.
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Continuing A Mentor's CAR T Work
- Tatum continued Todd Allen's CAR T work after his unexpected passing and focused on improving the targeting ectodomain.
- She optimized CD4-based CARs to enhance killing of HIV-infected cells expressing envelope.
Affinity Needs An Optimal Window
- Tatum reports higher-affinity CD4 CARs improved target killing but cautions against too-high affinity.
- She highlights an optimal affinity window to balance potency and re-engagement.
A 70‑bp Bug And A Breakthrough
- Tatum describes troubleshooting a 70 bp deletion blocking CAR expression and the relief of recloning success.
- Fixing that cloning error transformed her project's progress and morale.