The Mikhaila Peterson Podcast You’re Treating the Wrong Problem | Dr. Chris Masterjohn EP 231
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Apr 30, 2026 
Dr. Chris Masterjohn, PhD in nutritional sciences and founder of mito.me, studies mitochondrial function and personalized biochemical testing. He discusses mitochondrial roots of chronic illness. Short takes cover why carnivorous and ketogenic approaches can help or fail, how SSRIs and benzodiazepines impact mitochondria, supplement intolerance from methylation and sulfur issues, and practical food-based strategies for B vitamins.
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How An All Meat Diet Can Reduce Chronic Inflammation
- The lion/all-meat diet can help inflammation by supplying carnitine and reducing carbs that fuel pro-inflammatory T cells.
- Masterjohn notes T cells in active inflammation run on carbohydrate and glutamine; removing carbs reduces T-cell activation while meat supplies carnitine.
Inflammation Can Signal Mitochondrial Carnitine Needs
- Inflammatory cytokines like TNF-alpha can be compensatory signals to import carnitine into cells when mitochondria struggle.
- Blocking TNF-alpha (biologics) can stop visible inflammation but worsen mitochondrial carnitine shortage and provoke mental symptoms.
Raise Nutrients Through Food Before Using Supplements
- If supplements cause intolerance, try raising nutrient levels through diet in small, tolerable increments before testing or high-dose interventions.
- Masterjohn suggests foods can supply milligram-level needs that supplements overshoot and provoke reactions.